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Of the various theories proposed, the free radical theory of aging states that it is the shift in antioxidant\/pro\u2010oxidant balance that leads to increased oxidative stress, dysregulation of cellular function and aging. It has been proved that accumulated damage by free radicals produced by exposure to ultraviolet (UV) radiation results in extensive damage to the soft skin tissues, which is commonly known as \u201cphotoaging\u201d. Although the human body has built\u2010in antioxidant mechanisms to suppress uncontrolled free radicals, these mechanisms may at times fail due to overwhelming production of toxic radicals. This is where supplemental antioxidants can play a vital role in restoring the balance, lack of which produces visible wrinkling and premature aging. Sesamol, a highly acclaimed antioxidant, was selected as a suitable antioxidant to investigate in this study, and is for the first time shown to counter UV\u2010induced oxidative stress (in terms of both biochemical and histopathological changes) in mouse skin. The source of radiation was a 300\u2010W UV lamp, and mice of the lacca strain were chosen as an animal model for this study. Free radical levels generated were estimated using the Ohkawa method for estimation of lipid peroxidation in animal tissues. The results from biochemical and histopathological investigations clearly confirm that the sesamol formulation is effective in preventing photodamage (lesions, ulcers and changes in skin integrity) due to chronic UV exposure.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02537.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T16:42:58Z","timestamp":1141058578000},"page":"200-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Development and evaluation of sesamol as an antiaging agent"],"prefix":"10.1111","volume":"45","author":[{"given":"Shringi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu Pal","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"601","article-title":"Ageing","volume":"95","author":"Bhattacharyya A.","year":"1997","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_4_3_2","first-page":"90","article-title":"Free radicals and ageing","volume":"23","author":"Leake CD.","year":"1968","journal-title":"Geriatrics"},{"key":"e_1_2_4_4_2","first-page":"106","article-title":"Free radicals and ageing","volume":"95","author":"Jolly JG.","year":"1997","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/11.3.298"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02432509"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/rej.1.1999.2.15"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/47.4.B107"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199303010-00006"},{"key":"e_1_2_4_10_2","first-page":"109","volume-title":"Experimental protocols for reactive oxygen and nitrogen species","author":"Yagi K.","year":"1988"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02042.x"},{"key":"e_1_2_4_12_2","unstructured":"OguraR SugiyamaM.Cellular membrane damage and lipid peroxide following exposure of the skin to ultraviolet trace. 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