{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:45:13Z","timestamp":1791323113454,"version":"4.3.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,1,6]],"date-time":"2005-01-06T00:00:00Z","timestamp":1104969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Ciclopirox is an antifungal agent and is effective against both Gram\u2010positive and Gram\u2010negative bacteria. These properties may give ciclopirox an advantage over other antifungal agents in the treatment of interdigital tinea pedis with secondary bacterial infection (dermatophytosis complex).<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To evaluate the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis with secondary bacterial infection in a prospective, randomized, double\u2010blind, placebo\u2010controlled clinical study.<\/jats:p><jats:p><jats:bold>Subjects and methods\u2002<\/jats:bold> One hundred subjects were enrolled in this 8\u2010week study (twice\u2010daily ciclopirox, 40 subjects; once\u2010daily ciclopirox, 40 subjects; twice\u2010daily vehicle, 20 subjects). Mycologic sampling, bacterial swabs, and evaluations for symptoms and signs of tinea pedis were performed on a target webspace at baseline and at weeks 2, 4, and 8. Global evaluations were made by both investigator and subject at each visit.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Ciclopirox gel applied once or twice daily significantly reduced the signs and symptoms at week 8, compared with vehicle (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0036). The mycologic cure and complete cure rates were much higher for the ciclopirox regimens than for the vehicle regimen. Early reduction of bacterial counts was noted with the ciclopirox regimens. There was no significant difference in the adverse event rate between the ciclopirox groups and the placebo group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Ciclopirox 0.77% gel, applied once or twice daily, is effective and safe in the treatment of tinea pedis interdigitalis with concomitant bacterial infection (dermatophytosis complex).<\/jats:p>","DOI":"10.1111\/j.1365-4632.2004.02559.x","type":"journal-article","created":{"date-parts":[[2005,6,28]],"date-time":"2005-06-28T17:27:13Z","timestamp":1119979633000},"page":"590-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis (dermatophytosis complex) in a randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"44","author":[{"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alayne R.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,1,6]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"163","article-title":"Diagnosis and management of common tinea infections","volume":"58","author":"Noble SL","year":"1998","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81264-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(09)80301-0"},{"key":"e_1_2_6_5_2","first-page":"850","volume-title":"Compendium of Pharmaceuticals and Specialties","author":"Loprox.","year":"2002"},{"key":"e_1_2_6_6_2","first-page":"1","article-title":"Ciclopirox: an overview","volume":"40","author":"Gupta AK","year":"2000","journal-title":"Int J Dermatol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(91)90075-V"},{"key":"e_1_2_6_8_2","first-page":"45","volume-title":"Laboratory Handbook of Dermatophytes.","author":"Summerbell RC","year":"1997"},{"key":"e_1_2_6_9_2","first-page":"409","article-title":"Evaluation of ciclopirox olamine cream for the treatment of tinea pedis: multicenter, double\u2010blind comparative studies","volume":"7","author":"Kligman AM","year":"1985","journal-title":"Clin Ther"},{"key":"e_1_2_6_10_2","first-page":"290","article-title":"Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis","volume":"11","author":"Aly R","year":"1989","journal-title":"Clin Ther"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.42.s1.6.x"},{"key":"e_1_2_6_12_2","first-page":"594","article-title":"Comparison of ciclopirox olamine 1% cream with ciclopirox 1%\u2013hydrocortisone acetate 1% cream in the treatment of inflamed superficial mycoses","volume":"10","author":"Lassus A","year":"1988","journal-title":"Clin Ther"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1991.tb00625.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2004.02559.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2004.02559.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T08:21:01Z","timestamp":1696926061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2004.02559.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,6]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1111\/j.1365-4632.2004.02559.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2004.02559.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,6]]},"assertion":[{"value":"2005-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}