{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:58:42Z","timestamp":1791057522356,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,17]],"date-time":"2005-04-17T00:00:00Z","timestamp":1113696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Current treatment recommendations for malignant melanoma <jats:italic>in situ<\/jats:italic> include surgical excision with at least 0.5\u00a0cm margins. On the head or neck, obtaining adequate surgical margins for melanoma can be challenging and often disfiguring. In addition, some elderly patients may not be good surgical candidates and may request less aggressive interventions.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We report herein three cases of malignant melanoma <jats:italic>in situ<\/jats:italic> on the face treated with topical imiquimod cream.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Complete regression of malignant melanoma <jats:italic>in situ<\/jats:italic> was observed on treatment with 5% topical imiquimod cream. The varied treatment regimens, rationale for using imiquimod rather than performing surgery, and the possible mechanisms of action are discussed.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Topical imiquimod can be used successfully for the treatment of malignant melanoma <jats:italic>in situ<\/jats:italic> on the face.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2005.02582.x","type":"journal-article","created":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T09:04:50Z","timestamp":1115111090000},"page":"428-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Successful treatment of malignant melanoma <i>in situ<\/i> with topical 5% imiquimod cream"],"prefix":"10.1111","volume":"44","author":[{"given":"Carolyn M.","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caron M.","family":"Grin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M.","family":"Grant\u2010Kels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00041-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.1999.00311.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00691.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01597.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(98)00068-X"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01151.x"},{"key":"e_1_2_6_8_2","first-page":"1177","article-title":"Update on adjuvant interferon therapy for high\u2010risk melanoma","volume":"16","author":"Agarwala SS","year":"2002","journal-title":"Oncology (Huntingt)"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-003-0020-0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107954"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03787.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.945"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.943"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.944"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.7.1105"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni758"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.1.25"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0366-077X.2003.05637.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2005.02582.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2005.02582.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T04:45:16Z","timestamp":1696913116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2005.02582.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,17]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1111\/j.1365-4632.2005.02582.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2005.02582.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,17]]},"assertion":[{"value":"2005-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}