{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:56:13Z","timestamp":1787014573472,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:00:00Z","timestamp":1144195200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Frontal fibrosing alopecia (FFA) is an acquired scarring alopecia currently considered a clinical variant of lichen planopilaris (LPP). Our purpose was to examine the clinicopathological features of FFA. In addition, we investigated the similarities and differences between FFA and LPP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    Biopsies from the scalp lesions of eight patients with FFA and eight patients with LPP were microscopically analyzed. Two cases of FFA and four cases of LPP were studied using direct immunofluorescence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    In spite of the completely different clinical characteristics of FFA and LPP patients, the histopathological findings for the two entities were similar. Common microscopic findings for both FFA and LPP included an inflammatory lymphocytic infiltrate involving the isthmus and infundibulum of the hair follicles, the presence of apoptotic cells in the external root sheath, and a concentric fibrosis surrounding the hair follicles that resulted in their destruction with subsequent scarring alopecia. Biopsies taken from FFA patients showed less follicular inflammation and more apoptotic cells than those from LPP patients. In some cases of LPP, the inflammatory infiltrate involved the interfollicular epidermis, a finding never present in our FFA cases. Direct immunofluorescence was negative in the two cases of FFA studied and showed deposits of immunoglobulins and\/or complement in two of the four LPP cases examined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    The characteristic findings for FFA were more prominent apoptosis and less inflammation than found in LPP, along with spared interfollicular epidermis. FFA cases showed a rather characteristic histopathological pattern, although we could not find any clear\u2010cut histological differences between FFA and LPP.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02507.x","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T04:29:58Z","timestamp":1144211398000},"page":"375-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Frontal fibrosing alopecia versus lichen planopilaris: a clinicopathological study"],"prefix":"10.1111","volume":"45","author":[{"given":"Enrique","family":"Poblet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Piqu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690060100013"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050466"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70326-8"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00558.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.205"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050100273"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01131.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050760"},{"key":"e_1_2_5_10_2","first-page":"185","article-title":"Alopecia frontal fibrosa postmenop\u00e1usica: una variante de liquen plano folicular de localizaci\u00f3n peculiar","volume":"90","author":"Escalonilla P","year":"1999","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01140.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0213-9251(02)72563-X"},{"key":"e_1_2_5_13_2","first-page":"299","article-title":"Frontal fibrosing alopecia in a postmenopausal woman","volume":"60","author":"Lee WS","year":"1997","journal-title":"Cutis"},{"key":"e_1_2_5_14_2","first-page":"328","article-title":"Postmenopausal frontal fibrosing alopecia. Report of 3 cases","volume":"22","author":"Claude V","year":"2002","journal-title":"Ann Pathol"},{"key":"e_1_2_5_15_2","first-page":"1181","article-title":"Postmenopausal frontal fibrosing alopecia","volume":"140","author":"Camacho F","year":"1999","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_16_2","first-page":"203","article-title":"Frontal fibrosing alopecia","volume":"3","author":"Fiorucci MC","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_17_2","first-page":"749","article-title":"Band\u2010like alopecia of the forehead\u2010hair zone. Postmenopausal frontal fibrosing alopecia","volume":"53","author":"Heyer M","year":"2002","journal-title":"Hautarzt"},{"key":"e_1_2_5_18_2","first-page":"607","article-title":"Postmenopausal frontal fibrosing alopecia: 20 cases","volume":"130","author":"Vaisse V","year":"2003","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/9780203490662-16","volume-title":"An Atlas of Hair Pathology with Clinical Correlations","author":"Sperling LC","year":"2003"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050771"},{"key":"e_1_2_5_21_2","first-page":"2","article-title":"Alopecia: histologic diagnosis by transverse sections","volume":"13","author":"Templeton SF","year":"1996","journal-title":"Seminars Diagnostic Pathol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.68"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02507.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02507.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:42:12Z","timestamp":1696884132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02507.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02507.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02507.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2006-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}