{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:10:45Z","timestamp":1696914645091},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:00:00Z","timestamp":1144195200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim\u2002<\/jats:bold> To compare a subgroup of patients with borderline systemic lupus erythematosus (SLE) with those with classic lupus in order to determine whether the former subset is a separate entity or a forerunner to SLE.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A retrospective survey was undertaken of a database containing the clinical information of a total of 71 patients in an Abu Dhabi hospital setting over a 12\u2010year period. Data of interest were criterial and noncriterial features of SLE together with relevant laboratory tests.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fifty\u2010six patients had SLE and 15 were considered to have borderline SLE as they satisfied less than four criteria of classification. Age and female sex distribution were no different in the two subgroups, but the disease duration was shorter in patients with borderline lupus. The occurrence of arthropathy (nonerosive), serositis, thrombocytopenia, hemolytic anemia, and malar eruption was common to both subgroups. Patients with borderline SLE lacked other mucocutaneous manifestations of lupus and major organ disease involvement. A number of other clinical features were also observed in the latter subgroup, including antiphospholipid (APL) syndrome. In addition, patients with borderline SLE expressed a multiple autoantibody profile, but had lower titers of antinuclear factor (ANF) and anti\u2010double\u2010stranded DNA (anti\u2010dsDNA) antibodies than those with classic SLE. None progressed to full\u2010blown SLE after a mean period of follow\u2010up of 21.2\u00a0months.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In our patients, borderline SLE was milder than classic lupus, yet shared a wide spectrum of noncriterial features and also produced clinical subsets. The clinical heterogeneity and multiple antibody profile may suggest that borderline SLE is a forerunner to SLE rather than a separate entity. A regular and longer period of follow\u2010up is required, however, to ultimately determine the fate of these patients.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02508.x","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T08:29:58Z","timestamp":1144225798000},"page":"366-369","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Borderline systemic lupus erythematosus (SLE): a separate entity or a forerunner to SLE?"],"prefix":"10.1111","volume":"45","author":[{"given":"Haider M.","family":"Al Attia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6989.1257"},{"key":"e_1_2_6_5_2","first-page":"475","article-title":"Latent lupus","volume":"4","author":"Ganczarczyk L","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_2","first-page":"831","article-title":"Systemic lupus erythematosus. Differences between patients who do, and who do not, fulfill classification criteria at the time of diagnosis","volume":"7","author":"Lom\u2010Orta H","year":"1980","journal-title":"J Rheumatol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1989.00390110061013"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678919787"},{"key":"e_1_2_6_9_2","first-page":"2345","article-title":"Undifferentiated connective tissue disease: analysis of 83 patients with a minimum follow up of 5 years","volume":"29","author":"Mosca M","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_10_2","first-page":"585","article-title":"Five\u2010year follow\u2010up of 165 Italian patients with undifferentiated connective tissue diseases","volume":"17","author":"Danieli MG","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_11_2","first-page":"598","article-title":"Systemic lupus erythematosus","author":"Isenberg DA","year":"1993","journal-title":"Hospital Update"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/096120339900800601"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360309"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(92)90021-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120300678828073"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.1.89"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02508.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02508.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:42:15Z","timestamp":1696898535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02508.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02508.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02508.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2006-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}