{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:14:47Z","timestamp":1761016487282},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T00:00:00Z","timestamp":1140652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The classical management of acne calls for prolonged oral and\/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To test the effect of a single overnight application of a paste containing 0.25% miconazole nitrate on acne papules, and comparison with the effect of the same but unmedicated paste.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> Narrow\u2010band reflectance spectroscopy was used to assess the changes in <jats:italic>E<\/jats:italic> index (erythema) after overnight application of the pastes. In the first study, a total of 117 acne papules were assessed in 15 adolescents. Measurements of the <jats:italic>E<\/jats:italic> index were performed at 24\u2010h intervals for 4\u00a0days on acne papules and the surrounding normal\u2010looking skin. The last two assessments were performed the mornings preceding and following, respectively, a single application of the medicated paste. The second part of the study consisted of a double\u2010blind, split\u2010face study on 25 adolescents with acne. They applied each of the two formulations on a randomized part of the forehead. A total of 161 acne papules received the medicated paste and 160 received the same but unmedicated paste. Measurements were performed the mornings before and after the overnight treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In the first part of the study, no significant daily difference was observed between the three series of pretreatment <jats:italic>E<\/jats:italic> indices, on both acne papules and normal skin. The treatment did not affect the <jats:italic>E<\/jats:italic> index of normal skin. By contrast, it decreased significantly the <jats:italic>E<\/jats:italic> index of the acne papules. The second part of the study also showed that the medicated paste significantly decreased the <jats:italic>E<\/jats:italic> index of acne papules. This effect was significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) superior to that of the unmedicated paste.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A single overnight application of miconazole nitrate paste appears to reduce the erythematous aspect of acne papules.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02685.x","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T09:31:17Z","timestamp":1140687077000},"page":"316-319","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of a single overnight topical application of miconazole nitrate paste on acne papules"],"prefix":"10.1111","volume":"45","author":[{"given":"Caroline","family":"Flagothier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Vroome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Borgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Cauwenbergh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rald E.","family":"Pi\u00e9rard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000049398"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000067817"},{"key":"e_1_2_5_4_2","first-page":"65","article-title":"Comedolysis by a lipohydroxyacid formulation in acne prone subjects","volume":"13","author":"Uhoda E","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000067821"},{"key":"e_1_2_5_6_2","first-page":"4","article-title":"Physiopathology of acne vulgaris: recent data, new understanding of the treatments","volume":"14","author":"Pawin H","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000211297"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00921.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2004.00083.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02002901"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.018002149.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000220875"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160698"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077240"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250091"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02685.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02685.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:16:57Z","timestamp":1696900617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02685.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,23]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02685.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02685.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,23]]},"assertion":[{"value":"2006-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}