{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T07:48:54Z","timestamp":1744357734661},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Vitiligo of the lips is a common concern of great psychologic consequence. Medical therapies are often ineffective due mainly to the absence of hair follicles. The transfer of melanocytes or melanocyte\u2010bearing skin by a surgical procedure may repigment this condition. Only a few surgical modalities have been successful in this \u201cdifficult to treat\u201d site.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To assess the effectiveness of autologous melanocyte transfer by epidermal grafts for lip vitiligo and to review the literature on the surgical correction of lip vitiligo.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twenty\u2010six vitiligo patients (20 women and six men; age range, 13\u201343\u00a0years; mean, 26.8\u00a0years) having 31 affected lips with stable disease were included in the study. The suction blisters were raised using our own modified device on the lateral aspect of the thigh. The roofs of the blisters were transferred to the dermabraded recipient area. The dressing, together with the grafts, was removed on day 8. Patients were given photochemotherapy for 6\u00a0weeks. In addition, meta\u2010analysis of the published literature on the surgical management of lip vitiligo was also performed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Complete repigmentation was observed in 27 of the 31 lip areas (87%) in 23 of 25 patients (92%) in whom a follow\u2010up for 6\u00a0months or more was available. Complications observed were persistent hyperpigmentation in 12 lips and reactivation of herpes in one patient. Minimal hyperpigmentation was seen in most of the remaining lips. The results of the meta\u2010analysis revealed that the success rate varies from 32.5% to 100% with various surgical procedures.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Autologous melanocyte transfer is an effective and safe therapeutic option for stable vitiligo of the lips. It is cosmetically more acceptable, as there is no abnormal keratinization, which is a problem associated with dermo\u2010epidermal grafts.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02694.x","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T16:19:31Z","timestamp":1149005971000},"page":"747-750","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Autologous melanocyte transfer via epidermal grafts for lip vitiligo"],"prefix":"10.1111","volume":"45","author":[{"given":"Somesh","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashima","family":"Goel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrinder J.","family":"Kanwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhushan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"313","volume-title":"Roenigk and Roenigk's Dermatologic Surgery","author":"Greenway HT","year":"1996"},{"key":"e_1_2_5_3_2","first-page":"493","article-title":"Response to cosmetic disfigurement in patients with vitiligo","volume":"39","author":"Porter J","year":"1987","journal-title":"Cutis"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(97)00129-6"},{"key":"e_1_2_5_5_2","first-page":"76","volume-title":"Vitiligo","author":"Ortonne JP","year":"2002"},{"key":"e_1_2_5_6_2","first-page":"29","article-title":"Leucoderma of the lips: a clinical study","volume":"21","author":"Coondoo A","year":"1976","journal-title":"Indian J Dermatol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00702.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","unstructured":"GuptaS AjithC KanwarAJ et al.Surgical pearl: standardized suction syringe for epidermal grafting.J Am Acad Dermatol2005;52:348\u2013350.","DOI":"10.1016\/j.jaad.2004.06.041"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.29380.x"},{"key":"e_1_2_5_10_2","first-page":"26","article-title":"Surgical treatment in acrofacial vitiligo","volume":"60","author":"Shah BH","year":"1994","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91329-7"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80358-1"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.12.1543"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00097.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000076485"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199103000-00013"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1989.tb03129.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.11.1380"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630252775207"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.415"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02694.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02694.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:58:36Z","timestamp":1696903116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02694.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,30]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02694.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02694.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,30]]},"assertion":[{"value":"2006-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}