{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:16:10Z","timestamp":1777414570182,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>A 33\u2010year\u2010old Malay female presented to our clinic for the evaluation of nail pigmentation. She had been diagnosed with essential thrombocytosis 2\u00a0years previously, but had failed to return for follow\u2010up. She presented again to the hematology department with symptoms of giddiness, blurring of vision, and left\u2010sided weakness and was started on hydroxyurea 3\u00a0g\/day.<\/jats:p><jats:p>Hydroxyurea was stopped after 1\u00a0month of administration because of pancytopenia. Concurrent medications taken included anagrelide, buscopan, allopurinol, omeprazole, and sangobion. None of these medications are known to cause nail pigmentation.<\/jats:p><jats:p>She first presented to our department when she noticed nail pigmentation 7\u00a0weeks after starting hydroxyurea, but was otherwise well. There were no other cutaneous features of hyperpigmentation. Clinical examination revealed transverse bands which were seen on all 20 nails. These involved the proximal half of the fingernails and the proximal third of the toenails and were colored brown (see<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>).<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Transverse bands on all 10 fingernails 9\u00a0weeks after the commencement of hydroxyurea therapy<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD2709:IJD_2709_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02709.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T15:55:37Z","timestamp":1137772537000},"page":"1329-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A case of hydroxyurea\u2010induced transverse melanonychia"],"prefix":"10.1111","volume":"45","author":[{"given":"Rachael Yu Lin","family":"Teo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,23]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"19","article-title":"Clinical toxicity of chemotherapeutic agents: dermatological toxicity","volume":"9","author":"Dunagin WG","year":"1982","journal-title":"Semin Oncol"},{"key":"e_1_2_2_3_2","first-page":"647","article-title":"Hydroxyurea in the management of therapy resistant psoriasis","volume":"21","author":"Layron AM","year":"1989","journal-title":"Br J Dermatol"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00782.x"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00427-4"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120910"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-6938.2001.00947.x"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70379-8"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113471"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21207.x"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00447.x"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(80)90065-1"},{"key":"e_1_2_2_13_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-4362.1997.tb04194.x","article-title":"Longitudinal pigmented nail bands during hydroxyurea therapy","volume":"36","author":"Cakir B","year":"1997","journal-title":"Int J Dermatol"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80119-3"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70324-8"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30888-X"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02709.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02709.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T11:17:06Z","timestamp":1706872626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02709.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,23]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02709.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02709.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,23]]},"assertion":[{"value":"2006-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}