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We report the case of a 55\u2010year\u2010old woman with metastatic breast cancer, who developed nail dystrophic changes comprising Beau's lines, subungual hyperkeratosis, dyschromia and onycholysis early in the treatment with trastuzumab\/docetaxel. Nail alterations advanced with the continuation of therapy. This combination of nail changes, and its progressive course, are extremely rarely encountered with the use of taxanes alone. The cellular mechanisms of action of trastuzumab and docetaxel are discussed in regards to their potential synergy, which may explain the particularities and severity of nail alterations in this patient.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02731.x","type":"journal-article","created":{"date-parts":[[2006,4,20]],"date-time":"2006-04-20T03:37:09Z","timestamp":1145504229000},"page":"1334-1336","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Trastuzumab\/docetaxel\u2010induced nail dystrophy"],"prefix":"10.1111","volume":"45","author":[{"given":"Doru T.","family":"Alexandrescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Vaillant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Wiernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,18]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.46824.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18307"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.99.147"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1167"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04210-0"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921030-00004"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03692.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00616.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008218824342"},{"key":"e_1_2_4_11_2","first-page":"953","article-title":"Expression of the HER\u20102\/neu proto\u2010oncogene in normal human adult and fetal tissues","volume":"5","author":"Press MF","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12696796"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8498"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012999012192"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1997.tb03811.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.232"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1039.x"},{"key":"e_1_2_4_18_2","first-page":"1673","article-title":"The effect of trastuzumab\/docatexel combination on breast cancer angiogenesis: dichotomus effect predictable by the HIFI alpha\/VEGF pre\u2010treatment status?","volume":"23","author":"Koukourakis MI","year":"2003","journal-title":"Anticancer Res"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02731.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02731.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:52:16Z","timestamp":1696899136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02731.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,18]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02731.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02731.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,18]]},"assertion":[{"value":"2006-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}