{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:51:16Z","timestamp":1791143476791,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Beh\u00e7et's disease (BD) is a systemic inflammatory vasculitis of young adults with unknown etiology.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> The aim of this study was to determine the clinical features and outcome of BD in childhood.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> Seventeen patients with BD within a pediatric age group were studied since 1997.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Boys : girls ratio was 12:5. Familial cases were very frequent (45%). Oral aphthous ulcers were present in all patients (100%), genital aphthous ulcers were present in 16 (94%), ocular lesions in 4 (24%), erythema nodosum in 3 (18%), papulopustules in 8 (47%), joint symptoms in 13 (76%), mild gastrointestinal symptoms in 2 (12%), neurological involvement in 2 (12%), positive pathergy reactions in 13 (76%), and thrombophlebitis in 1 (6%). We used colchicine, systemic corticosteroids, cyclosporine, nonsteroidal anti\u2010inflammatory drugs, sulfasalazine, and topical agents for the treatment of children with BD.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The findings of BD in children are similar as in adults, but the frequency of familial cases is significantly higher.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02754.x","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T15:55:37Z","timestamp":1137772537000},"page":"713-716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Clinical features of Beh\u00e7et's disease in children"],"prefix":"10.1111","volume":"45","author":[{"given":"Murat","family":"Borlu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmit","family":"Uk\u015fal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayten","family":"Ferahba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Evereklioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70523-2"},{"key":"e_1_2_5_3_2","first-page":"1291","volume-title":"Arthritis and Allied Conditions","author":"Kastner DL","year":"1997"},{"key":"e_1_2_5_4_2","first-page":"1114","volume-title":"Textbook of Rheumatology","author":"Valente RM","year":"1997"},{"key":"e_1_2_5_5_2","first-page":"393","volume-title":"Nobel T\u0131p Kitabevleri","author":"Yurdakul S","year":"1994"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.6.350"},{"key":"e_1_2_5_7_2","first-page":"483","article-title":"Immunopathogenesis of Beh\u00e7et's disease","volume":"15","author":"Lehner T","year":"1999","journal-title":"Ann Med Interne"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.6.783"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb03447.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16994"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00559.x"},{"key":"e_1_2_5_12_2","first-page":"381","volume-title":"Beh\u00e7et's Disease. Proceedings of the 6th International Conference on Beh\u00e7et's Disease","author":"Schafaie N","year":"1993"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70368-3"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.7.655"},{"key":"e_1_2_5_15_2","first-page":"377","volume-title":"Beh\u00e7et's Disease. Proceedings of the 6th International Conference on Beh\u00e7et's Disease","author":"Hamza M","year":"1993"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.5.457"},{"key":"e_1_2_5_17_2","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","author":"International Study Group for Beh\u00e7et's Disease.","year":"1990","journal-title":"Lancet"},{"key":"e_1_2_5_18_2","first-page":"115","article-title":"Validation of the International Study Group criteria for Beh\u00e7et's disease","volume":"33","author":"O\u2019Neill TW","year":"1994","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.2.317"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.04.009"},{"key":"e_1_2_5_21_2","first-page":"502","article-title":"Juvenile Beh\u00e7et's disease in Israel","volume":"16","author":"Uziel Y","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.8.933"},{"key":"e_1_2_5_23_2","first-page":"255","article-title":"Familial occurrence of Beh\u00e7et's disease","volume":"40","author":"Nishiura K","year":"1996","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3928\/0191-3913-19980501-08","article-title":"Clinical features of pediatric Beh\u00e7et's disease","volume":"35","author":"Eldem B","year":"1998","journal-title":"J Pediatr Ophth Strab"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02754.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02754.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:59:27Z","timestamp":1696903167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02754.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,20]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02754.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02754.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,20]]},"assertion":[{"value":"2006-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}