{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:52:05Z","timestamp":1793404325651,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T00:00:00Z","timestamp":1137456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The high rate of morbidity and mortality resulting from long\u2010term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation.<\/jats:p><jats:p><jats:bold>Aims\u2002<\/jats:bold> This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In a double\u2010blind, placebo\u2010controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15\u00a0days of treatment an epithelialization index of the two groups was compared.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3\u00a0\u00b1\u00a01.7 vs. 24.4\u00a0\u00b1\u00a03.3, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Pilocarpine gel effectively treats PV.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02766.x","type":"journal-article","created":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T17:03:49Z","timestamp":1137517429000},"page":"743-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus 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