{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:20:32Z","timestamp":1774383632685,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Although genital ulceration with or without scar formation is an important manifestation of Beh\u00e7et's syndrome, formal data on the rate of genital scarring are lacking.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To study prospectively the frequency of genital scar formation after genital ulcers in patients with Beh\u00e7et's syndrome.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> One hundred and two patients (72 males and 30 females) with fresh genital ulcers presenting at a dedicated Beh\u00e7et's syndrome outpatient clinic were followed for 6\u00a0weeks. The ulcer location, size, and frequency of scar formation were noted. All patients were treated with similar topical therapy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Two hundred and ten genital ulcers were followed in both sexes. The rate of scar formation was 66.2% (102\/154) in male patients and 60.7% (34\/56) in female patients. When genital ulcers were stratified as a function of size, large genital ulcers (\u2265\u00a01\u00a0cm in diameter) developed scars more frequently than did smaller ulcers (&lt;\u00a01\u00a0cm). The rate of scar formation in male patients with large genital ulcers was 89.4% (59\/66) and with small ulcers was 48.9% (43\/88) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In females, all 19 large ulcers healed with scarring, and the same was true for 40.5% (15\/37) of the small ulcers (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a018.61, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> About two\u2010thirds of genital ulcers in Beh\u00e7et's syndrome leave scars. The rate of scar formation depends on the ulcer size.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02859.x","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T09:49:10Z","timestamp":1146217750000},"page":"554-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["The frequency of scarring after genital ulcers in Beh\u00e7et's syndrome: a prospective study"],"prefix":"10.1111","volume":"45","author":[{"given":"M. Cem","family":"Mat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadir","family":"Goksugur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burhan","family":"Engin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabahattin","family":"Yurdakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/31.5.299"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01741.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.6.784"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70523-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-9959(97)89290-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.12.1171"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10606.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00115.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2003.18.1.88"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-97931-6_35"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02859.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02859.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:10:14Z","timestamp":1696903814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02859.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,27]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02859.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02859.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,27]]},"assertion":[{"value":"2006-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}