{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:04:11Z","timestamp":1761894251473},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Background\u2002<\/jats:bold> Linear scleroderma occurs as two clinically distinct variants: the frontoparietal en coup de sabre type, and the torso\u2010extremity type. Antihistone antibodies (AHAs), which traditionally are markers for drug\u2010induced lupus, may also be linked to linear scleroderma.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Retrospective review of all patients presenting with linear scleroderma who had AHA titers measured.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 35\u00a0patients were identified. Twenty patients with linear scleroderma of the torso and\/or extremities comprised 14\u00a0pediatric patients (\u2264\u00a018\u00a0years\u00a0old; positive\u00a0AHA, 10\/14\u00a0=\u00a071%; positive\u00a0ANA, 3\/13\u00a0=\u00a023%) and six adults\u00a0(four\u00a0positive\u00a0AHA; five\u00a0positive\u00a0ANA). Among the 15\u00a0patients with frontoparietal linear scleroderma, en coup de sabre type, 11 were pediatric patients (positive\u00a0AHA, 5\/11\u00a0=\u00a045%; positive\u00a0ANA, 4\/11\u00a0=\u00a036%) and four were adults (1\u00a0positive\u00a0AHA\/ANA).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The two clinical variants of linear scleroderma are not only clinically distinct, but also may be serologically different. The AHA titers may be related to the extent of involvement as well as disease activity in linear scleroderma.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02891.x","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T09:54:54Z","timestamp":1142848494000},"page":"1296-1299","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antihistone antibodies in linear scleroderma variants"],"prefix":"10.1111","volume":"45","author":[{"given":"Rokea A.","family":"El\u2010Azhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole C.","family":"Aponte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey M.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry A.","family":"Homburger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(92)90087-F"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199609000-00014"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.121.3.345"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-6-849"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780260506"},{"key":"e_1_2_5_7_2","first-page":"2337","article-title":"Antinuclear antibodies in children with localized scleroderma","volume":"22","author":"Rosenberg AM","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70217-9"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/archderm.1994.01690100057009","article-title":"Antigen specificity of antihistone antibodies in localized scleroderma","volume":"130","author":"Sato S","year":"1994","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360815"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246474"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.8.470"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.759"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370618"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01262331"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02891.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02891.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:51:50Z","timestamp":1696899110000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02891.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,20]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02891.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02891.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,20]]},"assertion":[{"value":"2006-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}