{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:45:19Z","timestamp":1777524319036,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Objectives\u2002<\/jats:bold> Adenosine deaminase (ADA) is a non\u2010specific marker of the activation of the T cell, which has an important role in the etiology of Beh\u00e7et's disease (BD). The purpose of this study was to investigate the determination of ADA activity as an index of T\u2010lymphocyte function in BD, which is known to have an T\u2010cell\u2010mediated immune response.<\/jats:p><jats:p><jats:bold>Materials and Methods\u2002<\/jats:bold> Adenosine deaminase activities in both serum and erythrocytes were measured in 23\u00a0untreated patients with BD and in 20\u00a0healthy controls. The patients with BD were divided into two\u00a0groups: active\u00a0(<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and inactive\u00a0(<jats:italic>n<\/jats:italic>\u00a0=\u00a013).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> When compared with the control group, serum ADA activity was high\u00a0(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and erythrocyte ADA activity was significantly low\u00a0(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) in BD. Serum ADA activity of active BD was higher than that of inactive\u00a0BD\u00a0(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), but erythrocyte ADA activity was found to be lower in active\u00a0BD than inactive\u00a0BD\u00a0(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><jats:p><jats:bold>Comment\u2002<\/jats:bold> These findings may provide an additional benefit for the diagnosis of BD and sub\u2010typing of active and inactive BD.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02892.x","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T09:54:54Z","timestamp":1142848494000},"page":"1053-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum and erythrocyte adenosine deaminase activities in patients with Beh\u00e7et's disease"],"prefix":"10.1111","volume":"45","author":[{"given":"Filiz","family":"Canpolat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"\u00dcnver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Eskio\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eebnem","family":"K\u00f6sebalaban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selda Pelin Kartal","family":"Durmazlar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199901000-00009"},{"key":"e_1_2_5_4_2","first-page":"483","article-title":"Immunopathogenesis of Beh\u00e7et's disease","volume":"150","author":"Lehner T","year":"1999","journal-title":"Ann Med Interne"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-34-1-39"},{"key":"e_1_2_5_6_2","first-page":"506","article-title":"Skin hypersensitivity to streptococcal antigens and the induction of the systemic symptoms by antigens in Beh\u00e7et's disease: A multicentre study","volume":"16","author":"Mizushima Y","year":"1989","journal-title":"J Rheumatol"},{"key":"e_1_2_5_7_2","first-page":"1029","article-title":"Introduction of Beh\u00e7et's disease symptoms following dental treatment and streptoccal antigen skin test","volume":"15","author":"Mizushima Y","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5538.465"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/archderm.1974.01630030021003","article-title":"Lymphotoxicity in recurrent apthous stomatitis. 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