{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:31:56Z","timestamp":1782300716851,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Pemphigus vulgaris is characterized by the presence of autoantibodies to desmogleins. Multiple relapses and remission may occur during the course of the disease. The goal of this study was to determine whether direct immunofluorescence study has any value in detecting immunological remission of pemphigus vulgaris.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Fifty\u2010seven patients with pemphigus vulgaris who were in clinical remission for at least 3\u00a0months, while taking prednisolone 5\u20137.5\u00a0mg\/day, were recruited retrospectively for the study. Direct immunofluorescence study had been performed in all patients after a period of at least 3\u00a0months in clinical remission. Treatment had been discontinued in all patients with negative results of direct immunofluorescence.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Of 57 patients who were in clinical remission, 24 patients (42%) had negative and 33 patients (58%) had positive results of direct immunofluorescence. Eleven patients (46%) with negative results of direct immunofluorescence relapsed within the first year of the follow\u2010up period. Nine patients with negative direct immunofluorescence had a history of more than 6\u00a0months of clinical remission before direct immunofluorescence study. Among them, two patients (22%) relapsed. None of four patients with history of more than 12\u00a0months of clinical remission before a negative direct immunofluorescence study relapsed.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Negative direct immunofluorescence is an indicator of immunological remission in patients with pemphigus vulgaris after 6\u201312\u00a0months in clinical remission.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02916.x","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T09:54:54Z","timestamp":1142848494000},"page":"1308-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Value of direct immunofluorescence in predicting remission in pemphigus vulgaris"],"prefix":"10.1111","volume":"45","author":[{"given":"Kamran","family":"Balighi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Mansoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheida","family":"Chams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890260105016"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70111-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010040006002"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00504.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70060-5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb04165.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02497.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90213-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03659.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246938"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1001\/archderm.1978.01640240011003","article-title":"Fate of pemphigus antibody following successful therapy. Preliminary evaluation of pemphigus antibody determinations to regulate therapy","volume":"114","author":"O\u2019Loughlin S","year":"1978","journal-title":"Arch Dermatol"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.02916.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.02916.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:51:51Z","timestamp":1696899111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.02916.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,20]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1365-4632.2006.02916.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02916.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,20]]},"assertion":[{"value":"2006-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}