{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:43:08Z","timestamp":1773114188333,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Epstein\u2013Barr virus (EBV)\u2010associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To elucidate the possible association of EBV with CD30<jats:sup>+<\/jats:sup> anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>  <jats:italic>In situ<\/jats:italic> hybridization for EBV\u2010encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein\u20101 (LMP\u20101) were performed on formalin\u2010fixed, paraffin\u2010embedded skin specimens of 26 cases of LyP and 16 cases of CD30<jats:sup>+<\/jats:sup> ALCL involving the skin which were selected from six university hospital medical centers in South Korea.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>  <jats:italic>In situ<\/jats:italic> hybridization studies showed positivity of the neoplastic cells for EBER in two of 16 cases of CD30<jats:sup>+<\/jats:sup> ALCL and in none of the cases of LyP. One EBER\u2010positive case was cutaneous CD30<jats:sup>+<\/jats:sup> ALCL with concurrent lymph node involvement. The other was CD30<jats:sup>+<\/jats:sup> ALCL involving the skin and other organs, including lymph nodes, bone, lung, and spleen. Immunostaining for LMP\u20101 was also positive only for the two cases of EBER\u2010positive CD30<jats:sup>+<\/jats:sup> ALCL.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> LyP and primary cutaneous CD30<jats:sup>+<\/jats:sup> ALCL are very rarely associated with EBV in South Korea.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02951.x","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T15:50:51Z","timestamp":1153410651000},"page":"1312-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Epstein\u2013Barr virus in CD30<sup>+<\/sup> anaplastic large cell lymphoma involving the skin and lymphomatoid papulosis in South Korea"],"prefix":"10.1111","volume":"45","author":[{"given":"You Chan","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Ick","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Geol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Nam","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Hyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Jong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Kyoung","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"461","article-title":"The roles of human viruses in the pathogenesis of lymphoma","volume":"25","author":"Lyons SF","year":"1998","journal-title":"Semin Oncol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archderm.1996.03890270051007","article-title":"Absence of Epstein\u2013Barr virus in lymphomatoid papulosis: an immunohistochemical and in situ hybridization study","volume":"132","author":"Sangueza OP","year":"1996","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199208000-00009"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/99.3.289"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1182\/blood.V78.10.2666.2666","article-title":"Epstein\u2013Barr virus DNA and latent gene products in Ki\u20101 (CD30)\u2010positive anaplastic large cell lymphoma","volume":"78","author":"Herbst H","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_7_2","first-page":"553","article-title":"Epstein\u2013Barr virus and progression of non\u2010Hodgkin's lymphoma to Ki\u20101\u2010positive, anaplastic large cell phenotype","volume":"8","author":"DiGiuseppe JA","year":"1995","journal-title":"Mod Pathol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90232-X"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711700208"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.19352050.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb07613.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199501000-00006"},{"key":"e_1_2_6_13_2","first-page":"203","article-title":"Unlikely role of Epstein\u2013Barr virus in the pathogenesis of primary cutaneous CD30+ anaplastic large cell lymphoma","volume":"11","author":"Hellier I","year":"2001","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.10.013"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890450023003"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.132.3.335"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199611)180:3<236::AID-PATH653>3.0.CO;2-D"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199903)60:3<205::AID-AJH7>3.0.CO;2-J"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(00)00046-9"},{"key":"e_1_2_6_20_2","first-page":"1372","article-title":"Cutaneous T\u2010cell lymphomas (including rare subtypes). 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