{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:48:08Z","timestamp":1772160488802,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"\n A 58\u2010year\u2010old woman with ulcerative colitis of 5\u00a0years\u2019 duration was first seen in March 2002 with a 5\u2010month history of widespread erosions on the palate and gingiva, subtle scarring of the conjunctiva, and xerostomia accompanying a flare of ulcerative colitis. No skin lesions were observed. Direct immunofluorescence study performed on the oral mucosa showed a linear distribution of immunoglobulin G (IgG) and immunoglobulin A (IgA) at the dermal\u2013epidermal junction. Indirect immunofluorescence demonstrated the presence of circulating IgG anti\u2010basement membrane zone antibody. This patient was successfully treated with sulfasalazine 3\u00a0g\/day. Two years later, however, she developed extensive, well\u2010defined pustules and vegetating erosions on the skin, symmetrically localized in the inguinal and axillary folds and on the upper inner thighs (\n Fig.\u00a01<\/jats:ext-link>\n ). At that time, mucous membrane involvement, except for subtle scarring conjunctivitis, was not observed. Laboratory findings were normal, except for colonoscopy, which disclosed cobblestoning and histologically well\u2010circumscribed granulomas, confirming the diagnosis of ulcerative colitis.\n <\/jats:p>\n \n \n \n Extensive well\u2010defined pustules and vegetating erosions on the skin in the axillary (a) and inguinal (b) folds and upper inner thighs<\/jats:p>\n <\/jats:caption>\n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:fig>\n <\/jats:p>\n \n On the basis of the clinical features and the flare of coexistent ulcerative colitis, this patient was suspected of having pyoderma gangrenosum. Skin biopsy specimens showed acanthosis, papillomatosis, pseudocarcinomatous hyperplasia, and subepidermal blisters overlying an infiltrate of leukocytes and eosinophils, which also extended into the lower epidermis (\n Fig.\u00a02<\/jats:ext-link>\n ). Direct immunofluorescence of the perilesional skin demonstrated a linear distribution of IgG and IgA at the dermal\u2013epidermal junction.\n In vivo<\/jats:italic>\n \u2010bound IgG within the basement membrane zone was documented using laser scanning confocal microscopy, which disclosed the presence of immunoglobulins above collagen type IV and below laminin\u20105 (\n Fig.\u00a03<\/jats:ext-link>\n ). Indirect immunofluorescence study showed the presence of circulating IgG anti\u2010basement membrane zone antibody reacting with the roof and floor of salt\u2010split skin. Characterization of the target antigen (courtesy of Professor Hashimoto of Kurume University, Kurume, Japan) was unsuccessful, as Western immunoblot study on both epidermal and dermal extracts was negative, as was immunoblot with purified laminin\u20105 and enzyme\u2010linked immunosorbent assay with the NC16a epitope of BP180. Laser scanning confocal microscopy confirmed the diagnosis of cicatricial pemphigoid.\n <\/jats:p>\n \n \n \n Histopathology showing acanthosis, papillomatosis, and pseudocarcinomatous hyperplasia (a, \u00d7\u00a0150), subepidermal blisters overlying an infiltrate of leukocytes and eosinophils (b, \u00d7\u00a0300), and infiltrates extended into the lower epidermis (c, \u00d7\u00a0600) (hematoxylin and eosin stain)<\/jats:p>\n <\/jats:caption>\n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:fig>\n <\/jats:p>\n \n \n \n \n Laser scanning confocal microscopy demonstrating the presence of\n in vivo<\/jats:italic>\n \u2010bound immunoglobulin G (IgG) (green) below laminin\u20105 (a) and above collagen type IV (b) (red) (magnification, \u00d7\u00a02500)\n <\/jats:p>\n <\/jats:caption>\n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:fig>\n <\/jats:p>\n Therapy consisting of prednisone 40\u00a0mg each morning and sulfasalazine 1.0\u00a0g three times daily led to rapid improvement of the skin lesions, but did not affect the conjunctival lesions. After 4\u00a0weeks, prednisone was tapered and sulfasalazine was continued at a reduced dose of 0.5\u00a0g three times daily. At that time, only postinflammatory hyperpigmentation and atrophic scars were evident.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.02961.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T14:50:23Z","timestamp":1155048623000},"page":"299-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cicatricial pemphigoid vegetans"],"prefix":"10.1111","volume":"46","author":[{"given":"Katarzyna","family":"Wo\u017aniak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"G\u00f3rkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Olszewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezary","family":"Kowalewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585917"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.8.1007"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/120347540100500306"},{"key":"e_1_2_3_5_2","unstructured":"BrownJ SchwartzRA.Pyoderma vegetans.eMed Dermatol[Journal serial online]2005. 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