{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:45:55Z","timestamp":1790642755299,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T00:00:00Z","timestamp":1161648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Pemphigus is an autoimmune blistering skin disease mediated by auto\u2010antibodies directed against desmoglein proteins. There are only a few epidemiological studies on pemphigus. Our objective was to determine the epidemiological features of pemphigus in Macedonia, and to compare the results with those reported elsewhere.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Diagnosis in all cases was confirmed by histopathology and direct immunofluorescence. Binomial distribution testing and Fisher's exact\u2010test at the 0.01 level of significance were used to determine if particular demographic groups were over\u2010\/ under\u2010represented among the pemphigus patients.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> One hundred and thirty\u2010three new pemphigus cases were diagnosed in Macedonia from 1990\u20132004. The average annual incidence was 0.44\/100,000\u00a0inhabitants (SD\u00a0=\u00a00.17). The incidence doubled to 0.89 in 2001 during the local armed unrest. The disease did not affect either gender to a greater extent. The average annual incidence was 0.51 for ethnic Macedonians. Roma (Gypsies) had a statistically significantly higher incidence of pemphigus at 2.4\u00a0cases\/100,000\u00a0individuals. Ethnic Albanians had statistically significantly lower incidence of 0.1\u00a0cases\/100,000\u00a0individuals. The most common variant was pemphigus vulgaris (77.4%).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The annual incidence for pemphigus in Macedonia is 0.44\u00a0cases\/100,000\u00a0inhabitants. Most common form was pemphigus vulgaris. An epidemiological peak occurred in 2001 during the local armed conflict. Macedonian Roma had a sixfold higher incidence of pemphigus compared with the overall population; ethnic Albanians had a fourfold lower incidence.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.03010.x","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T16:13:27Z","timestamp":1161706407000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Epidemiology of pemphigus in Macedonia: A 15\u2010year retrospective study (1990\u20132004)"],"prefix":"10.1111","volume":"46","author":[{"given":"Marija T.","family":"V\u2019lckova\u2010Laskoska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri 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