{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:45:39Z","timestamp":1759333539100},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"A 10\u2010year\u2010old boy was diagnosed with non\u2010Herlitz junctional epidermolysis bullosa (nh\u2010JEB) shortly after birth when he developed blisters on his feet and under the toenails. His younger brother was also affected by nh\u2010JEB. Their parents were first cousins. Immunofluorescence mapping showed a blister in the lamina lucida and reduced staining with GB3 antibody against laminin V. Molecular analysis showed a homozygous mutation in the LAMC2<\/jats:italic> gene.<\/jats:p>The patient complained of intermittent inability to pass urine, causing significant suprapubic pain, anxiety, and general discomfort. He reported the development of blisters and erosions at the urethral meatus, which caused fusion of the meatal opening. In order to micturate, he had to tear apart the fused tissue, resulting in considerable pain.<\/jats:p>Physical examination revealed multiple healing erosions and atrophic scars, mainly on the legs (Fig.\u00a01<\/jats:ext-link>), and anonychia of most of the toenails. The walls of the urethral meatus were adherent (Fig.\u00a02<\/jats:ext-link>). The urethral meatus could not be opened using a moderate amount of pressure by the examining physicians.<\/jats:p>Extensive erosions were present on the lower legs, consistent with the diagnosis of non\u2010Herlitz junctional epidermolysis bullosa<\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>The sides of the penile urethral meatus have fused together, and could not be pulled apart with gentle or moderate pressure<\/jats:p><\/jats:caption>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p>Prevention of re\u2010stenosis of the urethral meatus was accomplished with the application of Mepilex\u00ae (M\u00f6lnlycke, Sweden) to the urethral meatus after each micturition, where it remained until the next episode of micturition. Since the institution of this care regimen 10\u00a0months ago, there has been no recurrence of the stenosis.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.03065.x","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T15:50:51Z","timestamp":1153410651000},"page":"1076-1077","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Urethral meatal stenosis in junctional epidermolysis bullosa: a rare complication effectively treated with a novel and simple modality"],"prefix":"10.1111","volume":"46","author":[{"given":"Adam I.","family":"Rubin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u2010David","family":"Fine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orli","family":"Wargon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9d\u00e9e F.","family":"Murrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,24]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0394-299"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12605898"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.9877"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0695-229"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117785"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0995-83"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000143200.86683.2c"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63291-9"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992288302200611"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80459-5"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45330-4"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2006.03065.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2006.03065.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:19:27Z","timestamp":1696918767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2006.03065.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,24]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1365-4632.2006.03065.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2006.03065.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,24]]},"assertion":[{"value":"2006-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}