{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:47:11Z","timestamp":1759333631171},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,27]],"date-time":"2006-07-27T00:00:00Z","timestamp":1153958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>A 25\u2010year\u2010old black man had a 20\u2010year history of disseminated plaques on his body. Two years before consultation he noticed several tumors on the genitalia. Physical examination revealed generalized, coalescing, hypopigmented plaques with a very defined and keratotic border that resembled actinic porokeratosis. (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>). Multiple verrucous and moist tumors were observed on the scrotum (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02<\/jats:ext-link>). His past medical history was unremarkable, and no family member had the disease.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Generalized, coalescing, hypopigmented plaques<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD3083:IJD_3083_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Multiple verrucous and moist tumors on the scrotum<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD3083:IJD_3083_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>Histology of the body lesions revealed hyperkeratosis with a horny\u2010layer, basket\u2010weave appearance, large and clear blue\u2013gray keratinocytes with finely granular cytoplasm and vacuolized nuclei, and abundant keratohyaline granules located in the upper epidermal layer (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f3\">Fig.\u00a03<\/jats:ext-link>). Scrotum biopsy showed hyperkeratosis, irregular acanthosis with papillomatosis, and koilocytic figures.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Hyperkeratosis with basket\u2010weave appearance of the horny layer and vacuolated blue\u2013gray keratinocytes (hematoxylin and eosin stain, \u00d720)<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD3083:IJD_3083_f3\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>The genital lesions were treated with monthly cryotherapy plus surgical excision with complete disappearance of the lesions. A decrease in ultraviolet exposure and daily sun\u2010block were encouraged for epidermodysplasia verruciformis lesions. After genital wart clearance, follow\u2010ups are being scheduled every 4\u00a0months, with no new lesions to date.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2006.03083.x","type":"journal-article","created":{"date-parts":[[2006,7,27]],"date-time":"2006-07-27T13:31:24Z","timestamp":1154007084000},"page":"199-201","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An unusual presentation of human papillomavirus (HPV) infection in a black epidermodysplasia verruciformis (EV) patient"],"prefix":"10.1111","volume":"46","author":[{"given":"Gloria","family":"Sanclemente","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9\u2010J.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis\u2010F.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen K.","family":"Tyring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690230092015"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01558.x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02768.x"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(04)93840-9"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01539.x"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1240.x"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199302000-00001"},{"key":"e_1_2_2_9_2","first-page":"139","article-title":"Verruciformis epidermodysplasia in a black woman with hyperpigmented macula of the palms","volume":"119","author":"Boudghene\u2010Stambouli O","year":"1992","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_2_10_2","first-page":"957","article-title":"Epidermodysplasia verruciformis: diagnostic difficulties in a patient of negroid race","volume":"117","author":"Ango\u2010Padonou F","year":"1990","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000250603"},{"key":"e_1_2_2_12_2","first-page":"367","article-title":"Epidermodysplasia verruciformis of Lewandowsky\u2013Lutz in a Negro","volume":"100","author":"Degos R","year":"1973","journal-title":"Ann Dermatol Syphiligr (Paris)"},{"key":"e_1_2_2_13_2","first-page":"588","article-title":"Lewandowsky\u2013Lutz verruciform epidermodysplasia in black Africans","volume":"16","author":"Bloc G","year":"1971","journal-title":"Bull Soc Med Afr Noire Lang Fr"},{"key":"e_1_2_2_14_2","first-page":"905","article-title":"Lutz and Lewandowsky on verruciform epidermodysplasia black skin.","volume":"68","author":"Merklen FP","year":"1961","journal-title":"Bull Soc Fr Dermatol Syphiligr"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01938833"},{"key":"e_1_2_2_16_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/jid.1984.15","article-title":"Clinical observations, virologic studies and treatment trials in patients with epidermodysplasia verruciformis, a disease induced by specific papillomaviruses","volume":"83","author":"Lutzner MA","year":"1984","journal-title":"J Invest Dermatol"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.1.357-361.2000"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.3.690-695.1995"},{"key":"e_1_2_2_19_2","first-page":"2621","volume-title":"Dermatology in General Medicine","author":"Jablonska S","year":"1993"},{"key":"e_1_2_2_20_2","first-page":"157","volume-title":"Papillomaviruses","author":"Orth G","year":"1986"},{"key":"e_1_2_2_21_2","first-page":"424","article-title":"Epidermodysplasia verruciformis. 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