{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T02:55:15Z","timestamp":1721012115057},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T00:00:00Z","timestamp":1176249600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mycosis fungoides (MF), a cutaneous T\u2010cell lymphoma, is usually characterized by cell features of T\u2010helper\u20102 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon\u2010\u03b3 (IFN\u2010\u03b3) for the treatment of CCR4+ MF. In this report, we describe two cases of CD4+, CCR4\u2013 MF successfully treated with IFN\u2010\u03b1, but not IFN\u2010\u03b3. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN\u2010\u03b1, but not IFN\u2010\u03b3, for CCR4\u2013 MF.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03221.x","type":"journal-article","created":{"date-parts":[[2007,4,28]],"date-time":"2007-04-28T15:49:09Z","timestamp":1177775349000},"page":"435-438","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interferon\u2010\u03b1 is effective for CD4+, CCR4\u2013 mycosis fungoides"],"prefix":"10.1111","volume":"46","author":[{"given":"Taku","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuhei","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Watabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hachiro","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190410001693560"},{"key":"e_1_2_5_3_2","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01856-0"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.1.129"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19610.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200311000-00005"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077303"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1054"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2340\/00015555-0017","article-title":"Effective control of rush progression of CD8 positive mycosis fungoides with pegylated interferon","volume":"86","author":"Fujimura T","year":"2006","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2003.01645.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30060-1"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.3.208"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-4-484"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12611877"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12398454"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood.V88.4.1383.bloodjournal8841383","article-title":"Sezary syndrome T\u2010cell clones display T\u2010helper 2 cytokines and express the accessory factor\u20101 (interferon gamma receptor beta chain)","volume":"88","author":"Dummer R","year":"1996","journal-title":"Blood"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2007.03221.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2007.03221.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:56:25Z","timestamp":1696888585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2007.03221.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1365-4632.2007.03221.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2007.03221.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"2007-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}