{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:56:11Z","timestamp":1787014571284,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,3]],"date-time":"2007-09-03T00:00:00Z","timestamp":1188777600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vitiligo is characterized by the selective destruction of melanocytes resulting in patches of skin depigmentation. Vitiligo is a therapeutic challenge. Eyebrows, eyelids and genital vitiligo are a therapeutic dilemma, especially in children. The possible side effects of topical corticosteroids and the difficulties for choosing any other adequate treatment option are a major concern. We present two children, one with vitiligo of the eyelids and the other with genital vitiligo, both treated with pimecrolimus 1% cream with almost full repigmentation of the lesions, showing pimecrolimus could be an adequate option for the treatment of vitiligo for these special vitiligo areas in children.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03282.x","type":"journal-article","created":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T06:54:15Z","timestamp":1189148055000},"page":"986-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Two therapeutic challenges: periocular and genital vitiligo in children successfully treated with pimecrolimus cream"],"prefix":"10.1111","volume":"46","author":[{"given":"Rubens Marcelo","family":"Souza Leite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Arag\u00e3o","family":"Craveiro Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1959.49"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03635.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.06.004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(03)00045-2"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.12.1514"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70194-X"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126250"},{"key":"e_1_2_5_9_2","first-page":"88","article-title":"Topical 0.05% clobetasol propionate versus 1% pimecrolimus ointment in vitiligo","volume":"15","author":"Coskun B","year":"2005","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_10_2","first-page":"1065","volume-title":"Andrew's Diseases of the Skin: Clinical Dermatology","author":"Odom RB","year":"2000"},{"key":"e_1_2_5_11_2","first-page":"333","article-title":"On the subject of serum antibodies to melanocytes in vitiligo","volume":"84","author":"Moelmann GE","year":"1985","journal-title":"J Invet Dermatol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12289743"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1997.tb02292.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00029-8"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.031"},{"key":"e_1_2_5_16_2","first-page":"215","article-title":"Recommendations (short version)","volume":"15","author":"Consensus Conference Management of atopic dermatitis in children","year":"2005","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.5.581"},{"key":"e_1_2_5_18_2","first-page":"21","article-title":"Therapeutic trends for the treatment of vitiligo","volume":"15","author":"Grimes PE","year":"2002","journal-title":"Cosmet Dermatol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","unstructured":"SchreiberSL CrabtreeGR.The mechanism of action of cyclosporin A and FK506.Immunol Today1992; 13: 136\u2013142.","DOI":"10.1016\/0167-5699(92)90111-J"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02121.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00269.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.00128.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2007.03282.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2007.03282.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T20:20:05Z","timestamp":1697314805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2007.03282.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1111\/j.1365-4632.2007.03282.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2007.03282.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"2007-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}