{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:02:30Z","timestamp":1781553750504,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> Pyoderma gangrenosum (PG) is a rare ulcerative inflammatory condition of unknown etiology. Therapy for PG involves local wound care along with topical and systemic anti\u2010inflammatory and other immunodulatory agents. Etanercept is one such immunomodulator with activity against the inflammatory cytokine, tumor necrosis factor.<\/jats:p><jats:p><jats:bold>Objective\u2003<\/jats:bold> To evaluate the efficacy and safety of etanercept in the treatment of PG ulcers.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> A retrospective analysis was performed on seven patients with 11 refractory PG ulcers treated with subcutaneous injections of etanercept (25\u201350\u00a0mg twice weekly).<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> All seven patients with PG responded well to etanercept. Eight of the 11 ulcers (73%) completely healed with the mean time of (12.5\u00a0weeks), while the other three ulcers had marked reduction in size (within 8\u201318\u00a0weeks). Etanercept was well tolerated. No serious side\u2010effects were reported. Only one patient discontinued the drug secondary to side\u2010effects.<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> Etanercept is an alternative treatment option for patients with refractory ulcers due to PG.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03286.x","type":"journal-article","created":{"date-parts":[[2007,10,3]],"date-time":"2007-10-03T07:00:55Z","timestamp":1191394855000},"page":"1095-1099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Etanercept for the treatment of refractory pyoderma gangrenosum: a brief series"],"prefix":"10.1111","volume":"46","author":[{"given":"Carlos A.","family":"Charles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argentina","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meggan R.","family":"Banta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Kirsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30632-0"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200105000-00015"},{"key":"e_1_2_5_4_2","volume-title":"Color Atlas and Synopsis of Clinical Dermatology Common and Serious Diseases","author":"Thomas BF","year":"2001"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655202320378338"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00334.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.7.861"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198003000-00003"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198512000-00011"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02385.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1994.tb01793.x"},{"key":"e_1_2_5_12_2","first-page":"326","article-title":"Treatment of pyoderma gangrenosum with methotrexate","volume":"57","author":"Teitel AD","year":"1996","journal-title":"Cutis"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90285-6"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00607.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(93)90209-X"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63571-4"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.4065\/75.8.842"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2000.03756.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.20022083.x"},{"issue":"1","key":"e_1_2_5_20_2","first-page":"3153","article-title":"Treatment of pyoderma gangrenosum (PG) complicating Crohn's disease (CD) with infliximab","volume":"120","author":"Hong JJ","year":"2001","journal-title":"Gastroenterology"},{"key":"e_1_2_5_21_2","first-page":"930","article-title":"Improvement of pyoderma gangrenosum and psoriasis associated with Crohn disease with anti\u2010tumor necrosis factor \u03b1 monoclonal antibody","volume":"137","author":"Tan MH","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07581.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655202320378338"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/713786537"},{"key":"e_1_2_5_25_2","first-page":"49","article-title":"Infliximab: a treatment option for ulcerative pyoderma gangrenosum","volume":"15","author":"Geren SM","year":"2003","journal-title":"Wounds"},{"key":"e_1_2_5_26_2","first-page":"441","article-title":"Treatment of pyoderma gangrenosum with etanercept","volume":"3","author":"McGowan JW","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_27_2","volume-title":"Etanercept (Enbrel) [package insert].","author":"Immunex","year":"2005"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb14706.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00311.x"},{"key":"e_1_2_5_30_2","unstructured":"Remicade [prescribing information]. 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