{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:57:23Z","timestamp":1780099043105,"version":"3.54.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The lidocaine 7%\u2013tetracaine 7% (LT) peel has been demonstrated to be useful for a variety of dermatologic applications, including cosmetic, laser, and vascular access procedures.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> To measure and evaluate the detectable plasma levels and safety of lidocaine and tetracaine in adult volunteers after a single application of an LT peel, a novel method of topical anesthesia that does not require occlusion.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> A randomized, factorial design study was used to evaluate the pharmacokinetic profile of lidocaine and tetracaine after a single application of the LT peel in adult volunteers (<jats:italic>n<\/jats:italic>\u00a0=\u00a036; mean age, 26.6\u00a0years). The LT peel was applied to the anterior surface of the left or right thigh of volunteers for 30, 60, or 90\u00a0min over a 50\u2010, 100\u2010, or 200\u2010cm<jats:sup>2<\/jats:sup> area. Venous blood samples were collected at 0, 30, 60, 90, 120, 150, 180, 210, 300, and 420\u00a0min after the initial application of the LT peel.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At all time points, plasma concentrations of lidocaine and tetracaine were below the limits of quantification for the assay: 100\u00a0ng\/mL and 5\u00a0ng\/mL, respectively. Because of the lack of concentrations above the limit of quantification, it was not possible to determine the pharmacokinetic parameters, other than the maximum concentrations of &lt;\u00a0100\u00a0ng\/mL for lidocaine and &lt;\u00a05\u00a0ng\/mL for tetracaine. A single application of the LT peel was well tolerated, and no study subject reported an adverse event.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> A single application of LT peel to up to 200\u00a0cm<jats:sup>2<\/jats:sup> of anterior thigh in adults with a duration of up to 90\u00a0min produces systemic levels of lidocaine and tetracaine that are of no clinical significance at all time points measured up to 420\u00a0min after the initial application.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03331.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T16:02:17Z","timestamp":1281628937000},"page":"87-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systemic exposure to lidocaine and tetracaine is low after an application of a lidocaine 7%\u2013tetracaine 7% peel in adults"],"prefix":"10.1111","volume":"47","author":[{"given":"Lazarre","family":"Ogden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgette","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Basta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106506"},{"key":"e_1_2_6_3_2","first-page":"17","article-title":"Topical anesthetics in dermatology","author":"Jegasothy M.","year":"2000","journal-title":"Cosmet Dermatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1997.tb00388.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.02100.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2003.03.003"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200008000-00009"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.02079.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20044"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29292.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2007.03331.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2007.03331.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:09:07Z","timestamp":1696874947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2007.03331.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,17]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1111\/j.1365-4632.2007.03331.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2007.03331.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,17]]},"assertion":[{"value":"2007-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}