{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:31:43Z","timestamp":1762101103668},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Subacute cutaneous lupus erythematosus (SCLE), a distinct clinical subset of lupus erythematosus, remains a therapeutic challenge, especially in cases resistant to topical and standard systemic therapy. Leflunomide, a novel antirheumatic drug, has shown efficacy in the treatment of systemic lupus erythematosus in pilot studies.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We report two patients with SCLE who demonstrated the spectrum of possible clinical responses to leflunomide therapy.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> One patient experienced a complete clinical remission of symptoms, whereas the other developed a massive skin reaction which was distinctly related to the commencement of leflunomide therapy.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> To our knowledge, this is the first time that remission and deterioration of SCLE by leflunomide therapy have been described.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03333.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T15:39:04Z","timestamp":1281627544000},"page":"83-86","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Leflunomide in subacute cutaneous lupus erythematosus \u2013 two sides of a coin"],"prefix":"10.1111","volume":"47","author":[{"given":"Anke","family":"Suess","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sticherling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,17]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010120007006"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04176.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.9.1175"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050151"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1610-0387.2003.03024.x"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1191\/096120301678416033"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1067sr"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2002.01539.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0353.2002.02621.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0303095"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00490.x"},{"key":"e_1_2_4_13_2","first-page":"1993","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Sontheimer DS","year":"1999"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(98)00007-8"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.45"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.019323"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01527.x"},{"key":"e_1_2_4_18_2","first-page":"724","article-title":"Subacute cutaneous lupus erythematosus precipitated by leflunomide","volume":"29","author":"Chan SK","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh586"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2007.03333.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2007.03333.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:09:09Z","timestamp":1696874949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2007.03333.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,17]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1111\/j.1365-4632.2007.03333.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2007.03333.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,17]]},"assertion":[{"value":"2007-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}