{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:25:57Z","timestamp":1777613157422,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Pemphigus vulgaris (PV) is a rare autoimmune blistering disease of the skin and mucous membranes. It varies in its clinical profile and epidemiologic characteristics in different parts of the world.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To determine the clinical features of PV in Iran in a prospective manner.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The study included 140 patients with newly registered PV attending our dermatology clinic between January 2003 and June 2004.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean age at the onset of the disease was 41.5\u00a0\u00b1\u00a015.7\u00a0years, with a female to male ratio of 1.59\u00a0:\u00a01. At presentation to our clinic, both skin and mucosal involvement was observed in 95 patients (67.9%). Cutaneous lesions without the involvement of the mucous membranes were seen in nine patients (6.4%), and exclusive mucosal involvement was present in 36 patients (25.7%). The most common initial localization of the disease was the oral cavity, which was involved in 93 patients (77.5%). The most frequent cutaneous and mucosal sites involved were the thorax and oral cavity, respectively.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Although minor differences were noted, the results of this study are in relatively good agreement with the literature with regard to the age, gender, and initial presentation of PV in Iran. Some skin sites, such as the scalp, thorax, and axilla, may be more commonly affected in men. Patients with initial mucosal lesions were significantly younger than those with initial cutaneous involvement. Mucosal lesions other than the oral mucosa may be more common than previously thought.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03334.x","type":"journal-article","created":{"date-parts":[[2007,11,3]],"date-time":"2007-11-03T11:24:56Z","timestamp":1194089096000},"page":"1166-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pemphigus vulgaris in Iran: a clinical study of 140 cases"],"prefix":"10.1111","volume":"46","author":[{"given":"Nafiseh","family":"Esmaili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheyda","family":"Chams\u2010Davatchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahin","family":"Valikhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Daneshpazhooh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Balighi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Hallaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Barzegari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Akhyani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra S.","family":"Ghodsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Mrotazavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra S.","family":"Naraghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siavash","family":"Toosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"41","volume-title":"Rook's Textbook of Dermatology","author":"Wojnarowska F","year":"2004"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02501.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0367-2"},{"key":"e_1_2_7_5_2","first-page":"558","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Stanley JR","year":"2003"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00428.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00864.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02218.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12612836"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00664.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00478.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-745.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/00007611-200194070-00015","article-title":"Pemphigus in the southeastern United States","volume":"94","author":"Woldegiogis S","year":"2001","journal-title":"South Med J"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01247.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01124.x"},{"key":"e_1_2_7_16_2","first-page":"287","article-title":"Feasibility of a registry of pemphigus in Italy: two years experience. 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