{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:56:13Z","timestamp":1787014573340,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Patients with immunodeficiency are prone to infestation with\n                    <jats:italic>Demodex folliculorum<\/jats:italic>\n                    mites. Ultraviolet (UV) radiation can lead to immunosuppression and sebaceous gland hyperplasia. Although some cases of demodicidosis related to UV radiation exposure have been reported, no studies have been performed on the incidence of\n                    <jats:italic>D.\u00a0folliculorum<\/jats:italic>\n                    and its clinical characteristics in patients receiving phototherapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To investigate the effects of phototherapy on the density of\n                    <jats:italic>D.\u00a0folliculorum<\/jats:italic>\n                    infestation and its clinical characteristics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    This was a cross\u2010sectional study. Forty\u2010five patients receiving phototherapy and 43 age\u2010 and sex\u2010matched healthy controls were enrolled to the study. The sociodemographic characteristics, occupational information, and skin types (2, 3, 4, or 5) of both patients and controls were carefully recorded. The dermatologic diseases requiring phototherapy, type and number of phototherapy treatments, and cumulative UV doses of all patients were noted. The clinical findings that may relate to demodicidosis were recorded. Standardized skin surface biopsies were taken from three anatomic regions (forehead, cheek, and nasal dorsum) and suspected lesions; five or more\n                    <jats:italic>D.\u00a0folliculorum<\/jats:italic>\n                    mites per square centimeter of skin was defined as demodicidosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Twelve (26.7%) patients received psoralen plus UV\u2010A (PUVA) and 33 (73.3%) received narrow\u2010band UV\u2010B. Demodicidosis was detected in 13 (28.9%) patients and three (7%) controls. The difference in the demodicidosis rate between patients and controls was statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.01). In eight of the 13 patients (61.5%) with demodicidosis, clinical demodicidosis was present. Demodicidosis was present in seven of the 12 patients (58.3%) receiving PUVA and in six of the 33 patients (18.2%) receiving narrow\u2010band UV\u2010B. The difference in demodicidosis rates between patients receiving PUVA and those receiving narrow\u2010band UV\u2010B was statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.02). A statistically significant difference was also found between the mean\n                    <jats:italic>D.\u00a0folliculorum<\/jats:italic>\n                    densities of patients and controls in all anatomic regions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    Demodicidosis should be included in the differential diagnosis of facial eruptions in patients receiving phototherapy.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03336.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T12:06:44Z","timestamp":1281614804000},"page":"72-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Clinical importance of\n                    <i>Demodex folliculorum<\/i>\n                    in patients receiving 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