{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:53:45Z","timestamp":1762458825981},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,17]],"date-time":"2007-12-17T00:00:00Z","timestamp":1197849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>A 50\u2010year\u2010old woman presented with itchy, multiple, flat, yellowish, waxy papules and plaques diffusely involving her face, trunk, and upper extremities for 5\u00a0years (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f1\">Fig.\u00a01<\/jats:ext-link>). Itching was moderate to severe in intensity and was episodic, without any identifiable aggravating or relieving factors. On rubbing the lesions with a blunt object erythema was elicited. Her ophthalmological examination was normal. Her complete hemogram was normal along with other routine investigations. Patient's slit skin smear for acid\u2010fast bacilli and rk39 dip\u2010stick ELISA for post\u2010kala\u2010azar dermal leishmaniasis were negative. Ultrasound examination of her abdomen was normal and skeletal survey showed no evidence of bony changes. Histological examination showed diffuse dense infiltrate of numerous mast cells filling up the papillary dermis and most of upper\u2010 and mid\u2010reticular dermis. Overlying epidermis showed moderate epidermal hyperplasia and hyperpigmentation. There was sparse scattering of neutrophils within the infiltrate. Extracellular mast cells granules were also seen (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#f2\">Fig.\u00a02<\/jats:ext-link>). Diagnosis of diffuse cutaneous mastocytosis of pseudoxanthomatous variety was made.<\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Pretreatment photographs of the patient; (a) face; (b) trunk<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD3358:IJD_3358_f1\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p><jats:fig><jats:caption><jats:p>Histopathology showing dense diffuse infiltrate of numerous mast cells filling up the papillary dermis and most of the upper and mid\u2010reticular dermis (H&amp;E; a, \u00d7100; b, \u00d7400)<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"urn:x-wiley:00119059:media:IJD3358:IJD_3358_f2\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:fig><\/jats:p><jats:p>The patient was prescribed treatment in the form of H1 and H2 blockers (fexofenadine and ranitidine) and trimethylpsoralen and ultraviolet A (PUVA) photochemotherapy. After 2 months of treatment, there has been marked improvement in the appearance and itching.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03358.x","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T16:06:19Z","timestamp":1281629179000},"page":"50-51","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pseudoxanthomatous mastocytosis"],"prefix":"10.1111","volume":"47","author":[{"given":"Neeraj","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Chand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,17]]},"reference":[{"key":"e_1_2_2_2_2","first-page":"1057","volume-title":"Skin Pathology","author":"Weedon D.","year":"2002"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04026.x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb06482.x"},{"key":"e_1_2_2_5_2","first-page":"736","volume-title":"Andrews\u2019 Disease of the Skin, Clinical Dermatology","author":"Odom RB","year":"2000"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2002.tb00280.x"},{"key":"e_1_2_2_7_2","first-page":"841","article-title":"Diffuse cutaneous mastocytosis","volume":"80","author":"Beer WW","year":"1968","journal-title":"Br J Dermatol"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2007.03358.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2007.03358.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:08:52Z","timestamp":1696874932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2007.03358.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,17]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1111\/j.1365-4632.2007.03358.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2007.03358.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,17]]},"assertion":[{"value":"2007-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}