{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:55:03Z","timestamp":1759010103374},"reference-count":24,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2007,10,22]],"date-time":"2007-10-22T00:00:00Z","timestamp":1193011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Pyoderma (bacterial superficial skin infection) is an extremely common disorder in tropical developing countries. In these settings, <jats:italic>Streptococcus pyogenes<\/jats:italic> is considered to be the main etiological agent. Apart from epidemics of poststreptococcal glomerulonephritis where mass treatment with intramuscular benzathine\u2010penicillin is recommended, no recommendation exists for the treatment of pyoderma in this setting. The aim of this study was to evaluate the efficacy of oral amoxicillin in the treatment of pyoderma in Mali, by comparison with oral erythromycin.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In Bamako, 132 patients with pyoderma, diagnosed and graded as \u201csevere\u201d on clinical grounds, were randomly assigned to an oral treatment by either amoxicillin (50\u00a0mg\/kg per day) or erythromycin; infections of the follicular appendage were excluded. Both drugs were associated with the topical application of povidone iodine. The patients were evaluated openly at the seventh day of treatment for cure or marked improvement of the clinical features, indicating successful treatment.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Three patients were lost to follow\u2010up. Treatment was successful in 57 of 64 patients treated with amoxicillin vs. 58 of 65 patients treated with erythromycin (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Amoxicillin was as efficacious as erythromycin in the treatment of severe pyoderma in Mali. Owing to its efficacy, added to high availability and low cost, this compound should be considered a first\u2010line treatment of this disorder in this country, and perhaps in other countries where this condition presents in a similar way.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03364.x","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T04:26:36Z","timestamp":1193199996000},"page":"19-22","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oral amoxicillin vs. oral erythromycin in the treatment of pyoderma in Bamako, Mali: an open randomized trial"],"prefix":"10.1111","volume":"46","author":[{"given":"Ousmane","family":"Faye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick J.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismaila","family":"Diawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Mah\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,22]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1001\/archderm.1975.01630220076006","article-title":"Bacterial skin infections in preschool and school children in coastal Tanzania","volume":"111","author":"Masawe AEJ","year":"1975","journal-title":"Arch Dermatol"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(77)90007-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90068-3"},{"key":"e_1_2_8_5_2","first-page":"550","article-title":"Morbidity pattern in children below three years attending a rural health centre in Haryana","volume":"26","author":"Kapil U","year":"1989","journal-title":"Indian Pediatr"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00140.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/00034983.1996.11813029","article-title":"Patterns of health\u2010care utilization and morbidity in a rural community near Lahore, Pakistan","volume":"90","author":"Suleman M.","year":"1996","journal-title":"Ann Trop Med Parasitol"},{"key":"e_1_2_8_8_2","unstructured":"World Health Organization.A review of WHO activities in the burden of the evidence for strategies to control group A streptococcal diseases. 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