{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:36:57Z","timestamp":1791239817456,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Acne is generally recognized as a disorder of young adults; however, the referral of patients aged over 25\u00a0years with acne is increasing. Disturbed androgen production in the ovaries or adrenal gland and impaired plasma transport of androgens in women with adult\u2010onset acne or acne associated with hirsutism have been described.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Thirty\u2010five white women with adult\u2010onset acne (onset after the age of 25\u00a0years) and hirsutism (A\u00a0+\u00a0H), 35 white women with adult acne without hirsutism (A\u00a0\u2013\u00a0H), and 35 age\u2010matched white female controls were recruited in this case\u2013control study. Serum levels of luteinizing hormone (LH), follicle\u2010stimulating hormone (FSH), total testosterone, dihydroepiandrosterone sulfate (DHEA\u2010S), and sex hormone binding globulin (SHBG) were determined in all patients and compared.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The mean SHBG, free androgen index (FAI), and DHEA\u2010S were significantly different between A\u00a0+\u00a0H and control subjects. The only significant difference between A\u00a0\u2013\u00a0H and control subjects was observed for DHEA\u2010S.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> DHEA\u2010S plays a key role in the pathogenesis of adult\u2010onset acne. Measurement of circulating androgens, including DHEA\u2010S, especially in patients presenting with adult\u2010onset acne and hirsutism, is helpful, and patients with elevated levels can benefit from hormonal therapy.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2007.03411.x","type":"journal-article","created":{"date-parts":[[2007,11,3]],"date-time":"2007-11-03T11:24:56Z","timestamp":1194089096000},"page":"1188-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Assessment of androgens in women with adult\u2010onset 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