{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T19:23:46Z","timestamp":1763580226116},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T00:00:00Z","timestamp":1200355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Oral isotretinoin is currently the most effective therapy for acne, but is associated with numerous adverse effects. To investigate the cardiac effects of isotretinoin, acne patients receiving isotretinoin for 6\u00a0months were studied.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Twenty\u2010six patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.8\u00a0mg\/kg\/day of isotretinoin (Roaccutane, Hoffman\u2010La Roche, Basle, Switzerland) for 6\u00a0months. All participants were assessed pretreatment and at the third month of therapy with 24\u2010h Holter monitoring of electrocardiography.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Twenty\u2010two patients completed the study (19 females and three males). Initial 24\u2010h Holter monitoring showed normal sinus rhythm in all patients, with a mean heart rate of 79\u00a0beats\/min (lowest, 63\u00a0beats\/min; highest, 97\u00a0beats\/min). At the third month of therapy, 24\u2010h Holter monitoring showed normal sinus rhythm in all patients, with a mean heart rate of 81\u00a0beats\/min (lowest, 67\u00a0beats\/min; highest, 91\u00a0beats\/min). All patients were in sinus rhythm throughout the recording period. None of the patients had supraventricular tachycardia or atrial arrhythmia.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> In this study, 6\u00a0months of isotretinoin therapy significantly improved acne and did not cause any cardiac adverse effects at a dose of 0.8\u00a0mg\/kg\/day.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2008.03341.x","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T12:00:11Z","timestamp":1253188811000},"page":"195-197","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Isotretinoin: is there any arrhythmic effect?"],"prefix":"10.1111","volume":"47","author":[{"given":"Yusuf","family":"Selcoki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan","family":"Gorpelioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faruk","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evren","family":"Sarifakioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adem","family":"Ozkara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguz","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kanbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Akcay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"881","article-title":"Global alliance to improve outcomes in acne. 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