{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:12:47Z","timestamp":1775635967282,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T00:00:00Z","timestamp":1200355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Certain factors are known to cause exacerbation of atopic dermatitis (AD), e.g. soap, detergent, dry skin, staphylococcal colonization, and herpes infection. Other factors are suspected, but not yet proven, e.g. yeasts belonging to the\n                    <jats:italic>Malassezia<\/jats:italic>\n                    genus. It is known that antimycotics may be beneficial in a small subset of adult patients with dermatitis affecting the head and neck region; however, it is not known whether AD patients, many of whom also have head and neck involvement, may also find antimycotics useful. A previous study has demonstrated no treatment difference in adult AD patients; however, the measurement method was criticized and 1% hydrocortisone cream may have too weak an effect in adult patients. Therefore, we designed this randomized, double\u2010blind, controlled trial to examine this question. Younger AD patients were recruited and different methods of measuring outcomes were used.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To evaluate the usefulness of topical antimycotic treatment as adjuvant therapy for flexural AD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods\u2002<\/jats:bold>\n                    This was a randomized, double\u2010blind, controlled trial in AD patients using one side of the elbow or knee as a control. There were three independent outcomes: (i) to compare the ability to relieve symptoms; (ii) to compare the ability to improve clinical signs; and (iii) to compare the ability to provide lasting clinical effects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    All three outcomes showed unequivocally that the addition of antimycotic did not provide extra benefit to the standard treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    The addition of antimycotic does not seem to provide extra benefit to AD patients, and the beneficial effect of this medication seems to be restricted to a small subset of adult patients with dermatitis affecting the head and neck region.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-4632.2008.03414.x","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T08:00:11Z","timestamp":1253174411000},"page":"187-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Is topical antimycotic treatment useful as adjuvant therapy for flexural atopic dermatitis: randomized, double\u2010blind, controlled trial using one side of the elbow or knee as a control"],"prefix":"10.1111","volume":"47","author":[{"given":"Alson W. K.","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis Kam\u2010lun","family":"Hon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benny","family":"Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,15]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"18","volume-title":"Rook's Textbook of Dermatology","author":"Friedmann PS","year":"2004"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04566.x"},{"key":"e_1_2_5_4_2","first-page":"18","volume-title":"Rook's Textbook of Dermatology","author":"Friedmann PS","year":"2004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2004.00097.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62821-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2340\/0001555575357360","article-title":"Pityrosporum ovale extracts increase interleukin\u20104, interleukin\u201010 and IgE synthesis in patients with atopic eczema","volume":"75","author":"Kroger S","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00526.x"},{"key":"e_1_2_5_9_2","first-page":"146","article-title":"Pityrosporum orbiculare\u2013 a pathogenic factor in atopic dermatitis of the face, scalp and neck?","volume":"114","author":"Waersted A","year":"1985","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00782.x"},{"key":"e_1_2_5_11_2","first-page":"18","volume-title":"Rook's Textbook of Dermatology","author":"Friedmann PS","year":"2004"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00082.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2824-2829.2005"},{"key":"e_1_2_5_14_2","first-page":"26","article-title":"Treatment of dermatitis of the head and neck with ketoconazole in patients with type 1 sensitivity to Pityrosporum orbiculare","volume":"2","author":"Clemmensen OH","year":"1983","journal-title":"Semin Dermatol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00207.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2340\/00015555754649","article-title":"Topical antimycotic treatment of atopic dermatitis in the head\/neck area. A double blind randomised study","volume":"75","author":"Broberg A","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780110811"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.034"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2008.03414.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2008.03414.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T14:16:07Z","timestamp":1696860967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2008.03414.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,15]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1365-4632.2008.03414.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2008.03414.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1099297.555525","asserted-by":"object"}]},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,15]]},"assertion":[{"value":"2008-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}