{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:14:17Z","timestamp":1785906857509,"version":"3.56.0"},"reference-count":124,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T00:00:00Z","timestamp":1200355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> New World leishmaniasis is an important endemic disease and public health problem in developing countries. The increase in ecologic tourism has extended this problem to developed countries. Few drugs have emerged over the past 50\u00a0years, and drug resistance has increased, such that the cure rate is no better than 80% in large studies. Despite these data, there has been no systematic review with a meta\u2010analysis of the therapy used in this important tropical disease. The aim of this study was to determine the best drug management in the treatment of cutaneous leishmaniasis (CL) in Latin America based on the best studies published in the medical literature.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> MEDLINE, LILACS, EMBASE, Web of Science, and Cochrane Library databases were searched to identify articles related to CL and therapy. Articles with adequate data on cure and treatment failure, internal and external validity information, and more than four patients in each treatment arm were included.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fifty\u2010four articles met our inclusion criteria and 12 were included in the meta\u2010analysis. Pentavalent antimonials were the most studied drugs, with a total of 1150 patients, achieving a cure rate of 76.5%. The cure rate of pentamidine was similar to that of pentavalent antimonials. Other drugs showed variable results, and all demonstrated an inferior response.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Although pentavalent antimonials are the drugs of choice in the treatment of CL, pentamidine showed similar results. Nevertheless, several aspects, such as cost, adverse effects, local experience, and availability of drugs to treat CL, must be considered when determining the best management of this disease, especially in developing countries where resources are scarce.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2008.03417.x","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T08:08:32Z","timestamp":1248250112000},"page":"109-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Treatment of New World cutaneous leishmaniasis \u2013 a systematic review with a meta\u2010analysis"],"prefix":"10.1111","volume":"47","author":[{"given":"Felipe Francisco","family":"Tuon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir Sabbaga","family":"Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Esther","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Machado","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Nicodemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente Amato","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,15]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1","article-title":"Treatment of American tegumentary leishmaniasis","volume":"26","author":"Amato VS","year":"2006","journal-title":"Bol Epidemiol Paul"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822006000100008"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.06.006"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X1994000800014"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762003000700001"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.03096.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.2.341"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb01993.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02051.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01730.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/clinids\/27.5.1332","article-title":"Leishmaniasis of the tongue in a renal transplant recipient","volume":"27","author":"Alrajhi AA","year":"1998","journal-title":"Clin Infect Dis"},{"key":"e_1_2_7_13_2","volume-title":"Manual de Controle da Leishmaniose Tegumentar Americana","author":"Minist\u00e9rio da Sa\u00fade","year":"2000"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.01.005"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.12.003"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-7-199704010-00006"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.07.004"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.3.417"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.2.165"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/322689"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/341406"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/429238"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/510588"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-2-9"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00062-3"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90160-B"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01526.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01527.x"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb03598.x"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485906X118495"},{"key":"e_1_2_7_31_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.4269\/ajtmh.2004.71.577","article-title":"Comparison of generic to branded pentavalent antimony for treatment of new world cutaneous leishmaniasis","volume":"71","author":"Soto J","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822000000600004"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822000000400009"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761996000200016"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.3.560"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90126-0"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.2.565"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3535070"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90061-1"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.58.192"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.69.309"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1086\/503371"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822006000200001"},{"key":"e_1_2_7_44_2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4269\/ajtmh.1990.43.623","article-title":"Infectivity of the subspecies of the Leishmania braziliensis complex in vivo and in vitro","volume":"43","author":"Rey JA","year":"1990","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91945-7"},{"key":"e_1_2_7_46_2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.4269\/ajtmh.1992.47.852","article-title":"Biochemical characterization and zymodeme classification of Leishmania isolates from patients, vectors, and reservoir hosts in Kenya","volume":"47","author":"Mebrahtu YB","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.456"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.3.528"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.466"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-3-199702010-00010"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1086\/516267"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90290-X"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821996000500011"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034980120064355"},{"key":"e_1_2_7_55_2","first-page":"35","article-title":"Management of American cutaneous leishmaniasis. Outcome apropos of 326 cases treated with high\u2010dose pentamidine isethionate","volume":"63","author":"Lightburn E","year":"2003","journal-title":"Med Trop (Mars)"},{"key":"e_1_2_7_56_2","first-page":"637","article-title":"Clinical overview of New World tegumentary leishmaniasis","volume":"62","author":"Lightburn E","year":"2002","journal-title":"Med Trop (Mars)"},{"key":"e_1_2_7_57_2","first-page":"545","article-title":"Epidemiologic surveillance of cutaneous leishmaniasis in Guiana. Summary of military data collected over 10\u00a0years","volume":"62","author":"Lightburn E","year":"2002","journal-title":"Med Trop (Mars)"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01633.x"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.72.133"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822003000300009"},{"key":"e_1_2_7_61_2","first-page":"492","article-title":"Treatment of mucocutaneous leishmaniasis with pentamidine isothionate","volume":"125","author":"Amato V","year":"1998","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.3731-3738.2002"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90094-R"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.10.6598"},{"key":"e_1_2_7_65_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1074\/jbc.270.47.28153","article-title":"Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen\u2010sensitive and \u2010resistant Trypanosoma brucei brucei","volume":"270","author":"Carter NS","year":"1995","journal-title":"J Biol Chem"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01414-3"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.3.380"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90248-7"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761990000300017"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00308.x"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203123261105"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1086\/513776"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(94)90237-2"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(94)90235-6"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821998000600001"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821996000600005"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821996000200014"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02597.x"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00022.x"},{"key":"e_1_2_7_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb00975.x"},{"key":"e_1_2_7_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.1.73"},{"key":"e_1_2_7_82_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1991.44.536"},{"key":"e_1_2_7_83_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4269\/ajtmh.1998.59.49","article-title":"Mucosal leishmaniasis due to Leishmania (Viannia) panamensis in Colombia: clinical characteristics","volume":"59","author":"Osorio LE","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_84_2","doi-asserted-by":"crossref","unstructured":"SampaioSA GodoyJT PaivaL DillonNL LacazCS.The treatment of American (mucocutaneous) leishmaniasis with amphotericin B.Arch Dermatol1960:82:627\u2013635.","DOI":"10.1001\/archderm.1960.01580040145026"},{"key":"e_1_2_7_85_2","doi-asserted-by":"publisher","DOI":"10.1086\/510494"},{"key":"e_1_2_7_86_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.03144.x"},{"key":"e_1_2_7_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02183.x"},{"key":"e_1_2_7_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb01603.x"},{"key":"e_1_2_7_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02429.x"},{"key":"e_1_2_7_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01049.x"},{"key":"e_1_2_7_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1991.tb04878.x"},{"key":"e_1_2_7_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb02593.x"},{"key":"e_1_2_7_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/9.Supplement_1.S57"},{"key":"e_1_2_7_94_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.125.11.1540"},{"key":"e_1_2_7_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90028-D"},{"key":"e_1_2_7_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.5.1221"},{"key":"e_1_2_7_97_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/AAC.43.1.172","article-title":"Experimental evaluation of second\u2010line oral treatments of visceral leishmaniasis caused by Leishmania infantum","volume":"43","author":"Gangneux JP","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_7_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(00)90077-8"},{"key":"e_1_2_7_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.01133.x"},{"key":"e_1_2_7_100_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761995000400020"},{"key":"e_1_2_7_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb03595.x"},{"key":"e_1_2_7_102_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb00622.x"},{"key":"e_1_2_7_103_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00021.x"},{"key":"e_1_2_7_104_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822002000500009"},{"key":"e_1_2_7_105_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821996000500007"},{"key":"e_1_2_7_106_2","first-page":"87","article-title":"Tratamento da leishmaniose tegumentar americana pelo antimoniato de N\u2010metil\u2010glucamina","volume":"66","author":"Kopke LF","year":"1991","journal-title":"An Bras Dermatol"},{"key":"e_1_2_7_107_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821999000500010"},{"key":"e_1_2_7_108_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821999000500009"},{"key":"e_1_2_7_109_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821997000600003"},{"key":"e_1_2_7_110_2","first-page":"189","article-title":"Avaliacao do tratamento da leishmaniose cutaneo\u2010mucosa com tres esquemas diferentes de antimoniais pentavalentes","volume":"64","author":"Sampaio RN","year":"1989","journal-title":"An Bras Dermatol"},{"key":"e_1_2_7_111_2","first-page":"361","article-title":"Tratamento da leishmaniose tegumentar aericana","volume":"60","author":"Talhari S","year":"1985","journal-title":"An Bras Dermatol"},{"key":"e_1_2_7_112_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.66.147"},{"key":"e_1_2_7_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.1.47"},{"key":"e_1_2_7_114_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.72.421"},{"key":"e_1_2_7_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.03.009"},{"key":"e_1_2_7_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(94)90517-7"},{"key":"e_1_2_7_117_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4269\/ajtmh.1991.45.92","article-title":"Placebo controlled treatment of Ecuadorian cutaneous leishmaniasis","volume":"45","author":"Guderian RH","year":"1991","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_118_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.3.381"},{"key":"e_1_2_7_119_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1990.42.43"},{"key":"e_1_2_7_120_2","doi-asserted-by":"crossref","first-page":"960","DOI":"10.4269\/ajtmh.1999.61.960","article-title":"Response of cutaneous leishmaniasis (chiclero's ulcer) to treatment with meglumine antimoniate in Southeast Mexico","volume":"61","author":"Vargas\u2010Gonzalez A","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_7_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90292-L"},{"key":"e_1_2_7_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)93053-4"},{"key":"e_1_2_7_123_2","doi-asserted-by":"publisher","DOI":"10.1086\/324161"},{"key":"e_1_2_7_124_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01633.x"},{"key":"e_1_2_7_125_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821999000400008"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2008.03417.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2008.03417.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:17:38Z","timestamp":1696875458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2008.03417.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,15]]},"references-count":124,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1365-4632.2008.03417.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2008.03417.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,15]]},"assertion":[{"value":"2008-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}