{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:02:39Z","timestamp":1765609359450},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T00:00:00Z","timestamp":1206662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Necrobiosis lipoidica diabeticorum (NLD) is a granulomatous skin reaction found in &lt;\u00a01% of diabetic patients. Our purpose was to determine if NLD represented areas of cutaneous ischemia.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Using laser Doppler flowmetry, we measured cutaneous blood flow in nine diabetic patients at NLD lesions and at contiguous uninvolved sites. Flow values were also determined at several reference sites noncontiguous with the NLD lesions and compared to age\u2010 and sex\u2010matched controls: 24 diabetic subjects without skin abnormalities, 18 diabetic patients with dermopathy, and 40 nondiabetic subjects.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> NLD lesions exhibited significantly higher blood flow (4.8\u00a0\u00b1\u00a00.7\u00a0ml\/min\/100\u00a0g) than areas of unaffected skin close to the lesions (1.2\u00a0\u00b1\u00a00.1\u00a0ml\/min\/100\u00a0g) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 for both comparisons). There were no significant differences in flow between normal skin sites in NLD patients and normal sites in diabetic patients without skin lesions.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our findings refute the hypothesis that NLD is a manifestation of microvascular ischemic disease of the skin. The increased blood flow seen in NLD lesions suggests an ongoing inflammatory process.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2008.03549.x","type":"journal-article","created":{"date-parts":[[2008,3,29]],"date-time":"2008-03-29T11:14:35Z","timestamp":1206789275000},"page":"354-358","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Skin blood flow in necrobiosis lipoidica diabeticorum*"],"prefix":"10.1111","volume":"47","author":[{"given":"Binh","family":"Ngo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Wigington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristie","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Huerter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Hillman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Adler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Rendell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,28]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"179","article-title":"Eigentumlich disseminierte degeneration des bindegewebes der haut bie einem diabetiker","volume":"32","author":"Oppenheim M.","year":"1929","journal-title":"A Hautkr"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02069897"},{"key":"e_1_2_7_4_2","first-page":"654","volume-title":"Skin Signs of Systemic Disease","author":"Braverman IM","year":"1981"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000420004"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1966.01600210008002"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80248-X"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","unstructured":"VerottiA ChiarelliF MaerioP MorgeseG.Necrobiosis lipoidica diabeticorum in children and adolescents: a clue for underlying renal and retinal disease.Pediatr Dermatol1995;12:220\u2013223.","DOI":"10.1111\/j.1525-1470.1995.tb00162.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.01935.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580130141023"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03081.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1964.01600060024004"},{"key":"e_1_2_7_13_2","first-page":"681","article-title":"Peripheral blood flow in patients with necrobiosis lipoidica diabeticorum","volume":"34","author":"Jahr U","year":"1979","journal-title":"Z Gesamte Inn Med"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.104969"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb00977.x"},{"key":"e_1_2_7_16_2","first-page":"68","article-title":"Tip II Diabetes mellitusta dermatolojik mikrovaskuler komplikasyonlar ve diabetik retinopati","volume":"9","author":"Erbagci Z","year":"1999","journal-title":"T Klin Dermatol"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1995.tb00162.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2337\/diab.38.7.819","article-title":"Microvascular blood flow, volume, and velocity measured by laser Doppler techniques in insulin dependent diabetes","volume":"38","author":"Rendell M","year":"1989","journal-title":"Diabetes"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90193-F"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00547-003-0947-9"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.10.1248"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1364\/AO.20.002097"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02442300"},{"key":"e_1_2_7_24_2","first-page":"73","article-title":"Non\u2010invasive measurement of skin blood flow, comparison between plethysmography, laser Doppler flowmeter and heat thermal clearance method","volume":"5","author":"Saumet JL","year":"1986","journal-title":"Int J Microcirc Clin Exp"},{"key":"e_1_2_7_25_2","first-page":"116","article-title":"Endoscopic measurement of gastric mucosal flow by laser Doppler velocimetry. 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