{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T20:07:09Z","timestamp":1767125229534},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,5,31]],"date-time":"2010-05-31T00:00:00Z","timestamp":1275264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The purpose of the study was to evaluate the possible role of stress before the onset\/extension\/recurrence of psoriasis.<\/jats:p><jats:p><jats:bold>Patients and method\u2002<\/jats:bold> One hundred and sixty\u2010nine outpatients with psoriasis and 169 age and gender matched controls were enrolled. The design was a case\u2010control study (controls had skin diseases with low psychosomatic component). Stressful life events were evaluated using Holmes and Rahe\u2019s Social Readjustment Rating Scale.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In the psoriatic group, there was a female predominance (66%) and a median age 47.55\u2003years (SD\u2003=\u200320.32). In all, 10.65% of patients had family history of psoriasis. More than 54% of cases experienced at least one stressful event (47.36% for onset, 63.51% for recurrence\/extension), compared with 19.52% of controls (\u03c7<jats:sup>2<\/jats:sup>\u2003=\u200342.71, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). The odds ratio was 4.92. There was a significant difference in the mean number of stressful events between patients and controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Women with psoriasis vulgaris and men with guttate psoriasis seemed to be more sensitive to stressful events. We divided the events described by Holmes and Rahe into three categories: family, personal, and job\/financial problems. Family matters were mentioned by 42.7% of psoriatic patients, statistically significant compared with controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). In 35% of psoriatic cases, \u201cthe stressful event\u201d was represented by the illness\/death of someone dear. Both \u201cpersonal\u201d (25.6%; <jats:italic>P<\/jats:italic>\u2003=\u20030.02) and \u201cjob\/financial problems\u201d (31.6%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) were significantly different compared with controls.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Stressful events could be highly related to psoriasis (especially in recurrences\/extensions). Problems related to family are the most often involved with counseling being suggested.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2009.04367.x","type":"journal-article","created":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T03:58:34Z","timestamp":1275364714000},"page":"636-641","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Life events involvement in psoriasis 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