{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T21:52:48Z","timestamp":1772401968849,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Drug\u2010induced hypersensitivity syndrome (DIHS\/DRESS) is a severe adverse systemic reaction. Reactivation of human herpesvirus (HHV) family members other than HHV\u20106 has been reported in patients with DIHS. Reactivation of HHV family members is generally characterized by increased serum antibody titers against the virus. By contrast, clinical symptoms caused by viral reactivation are relatively rare.<\/jats:p><jats:p><jats:bold>Method\u2002<\/jats:bold> We report a case of DIHS with intractable genital ulcers from reactivation of herpes simplex virus (HSV) in accordance with reactivation of HHV\u20106 and cytomegalovirus (CMV).<\/jats:p><jats:p><jats:bold>Result\u2002<\/jats:bold> Twenty\u2010two days after the onset of the rash, the patient developed intractable genital ulcers that were resistant to treatment. Histological examination of the ulcers revealed necrotic degeneration in the epidermal cells, with giant cells containing inclusion bodies and marked lymphocytic infiltration in the upper dermis. Immunohistochemical staining with antibodies reactive to HSV or CMV showed that these giant cells were positive for HSV but negative for CMV.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Genital herpes is a common skin disease. However, our case was considered to be a DIHS\u2010associated symptom, not an accidental complication, as the symptoms were severe and resistant to treatment.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2009.04441.x","type":"journal-article","created":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T03:58:34Z","timestamp":1275364714000},"page":"700-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intractable genital ulcers from herpes simplex virus reactivation in drug\u2010induced hypersensitivity syndrome caused by 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