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Although it is distinct from systemic polyarteritris nodosa in that it lacks significant internal organ involvement, extra\u2010cutaneous manifestations may be evident. Commonly encountered symptoms include fever, malaise, myalgias, arthralgias, and paresthesias. Exclusion of systemic polyarteritis nodosa is essential in diagnosis. The clinical course is chronic with remissions, relapses, and a favorable prognosis. Mild cases may resolve with nonsteroidal anti\u2010inflammatory drugs. If more severe, treatment with systemic corticosteroids generally achieves adequate response; however, adjunctive therapy is often necessary to allow reduction in steroid dosage.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04522.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T21:24:21Z","timestamp":1444771461000},"page":"750-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Cutaneous polyarteritis nodosa: a comprehensive review"],"prefix":"10.1111","volume":"49","author":[{"given":"Aaron Joseph","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,21]]},"reference":[{"key":"e_1_2_11_2_2","first-page":"484","article-title":"Ueber eine nicht bisher beschriebene eigenh\u00fcmliche Arterienerkrankung (Periarteritis Nodosa), die mit Morbus Brightii und rapid fortschreitender allgemeiner Muskell\u00e4hmung einhergeht","volume":"1","author":"Kussmaul A","year":"1866","journal-title":"Dtsch Arch Klin Med"},{"key":"e_1_2_11_3_2","first-page":"350","article-title":"Ueber Polyarteritis acuta nodosa (sogenannte Periateritis nodosa), und ihre Beziehungen zur Polymyositis und Polyneuritis acuta","volume":"34","author":"Ferrari E","year":"1903","journal-title":"Beitr Pathol Anat"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1931.tb18345.x"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1972.tb16181.x"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1965.01600170084015"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80656-1"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70020-T"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.03.065"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.6601645.x"},{"key":"e_1_2_11_11_2","first-page":"868","article-title":"Cutaneous polyarteritis nodosa: a case report and literature review","volume":"27","author":"Khoo BP","year":"1998","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_11_12_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/archderm.1974.01630090045009","article-title":"Cutaneous periarteritis nodosa","volume":"110","author":"Diaz\u2010Perez JL","year":"1974","journal-title":"Arch Dermatol"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0898-2"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.23081"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640250058016"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2006.21.2.371"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04624.x"},{"key":"e_1_2_11_18_2","first-page":"207","article-title":"Cutaneous polyarteritis nodosa in children: three cases","volume":"129","author":"Assicot C","year":"2002","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70216-0"},{"key":"e_1_2_11_20_2","first-page":"336","article-title":"Cutaneous polyarteritis nodosa after streptococcal necrotizing fasciitis","volume":"68","author":"Stein RH","year":"2001","journal-title":"Mt Sinai J Med"},{"key":"e_1_2_11_21_2","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1001\/archderm.1991.01680090084009","article-title":"Benign cutaneous polyarteritis nodosa. 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