{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:51:30Z","timestamp":1762271490796},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T00:00:00Z","timestamp":1290470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Onychomycosis is multifactorial in origin. Studies have suggested an autosomal dominant pattern of inheritance and human leukocyte antigen DR4 (HLA\u2010DR4) has been shown to protect against onychomycosis in an Ashkenazi Jewish population.<\/jats:p><jats:p><jats:bold>Aim\u2002<\/jats:bold> This study investigates HLA class II association in a Mexican Mestizo population with <jats:italic>Trichophyton rubrum<\/jats:italic> onychomycosis.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This was a prospective case\u2013control study. Mexican Mestizos with a clinical diagnosis of onychomycosis and culture positive for <jats:italic>T. rubrum<\/jats:italic> were recruited, together with age\u2010 and sex\u2010matched controls. First\u2010degree relatives were also investigated for onychomycosis. Case\u2013control samples were HLA typed by polymerase chain reaction sequence\u2010specific primer based analysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Twenty\u2010one cases and 42 controls were recruited with a mean age of 40\u2003years (range: 18\u201358\u2003years). HLA\u2010DR6 was found in seven (33%) cases and 19 (45%) controls [<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.023, odds ratio (OR)\u2003=\u20030.088, 95% confidence interval (CI): 0.01\u20130.71]. Six (29%) cases and three (7%) controls had an affected child (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.043, OR\u2003=\u20039.15, 95% CI: 1.07\u201378.31), and 13 (62%) cases and 12 (29%) controls had an affected first\u2010degree relative (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02, OR\u2003=\u20034.0, 95% CI: 1.1\u201314.3).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> These results suggest that HLA\u2010DR6 confers protection against the development of onychomycosis in a Mexican Mestizo population. Having an affected first\u2010degree relative significantly increases the risk of onychomycosis, suggesting genetic susceptibility.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04550.x","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T07:50:12Z","timestamp":1290498612000},"page":"1406-1409","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["HLA\u2010DR6 association confers increased resistance to <i>T. rubrum<\/i> onychomycosis in Mexican Mestizos"],"prefix":"10.1111","volume":"49","author":[{"given":"Daniel","family":"Asz\u2010Sigall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirio","family":"L\u00f3pez\u2010Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Elisa","family":"Vega\u2010Memije","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mar\u00eda","family":"Lacy\u2010Niebla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Garc\u00eda\u2010Corona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Ram\u00edrez\u2010Renter\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Granados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahreen","family":"Ameen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Diseases of the nails","author":"Pardo\u2010Castello V","year":"1960"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(02)00065-X"},{"key":"e_1_2_5_4_2","first-page":"84","article-title":"Las onicomicosis. 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