{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:37:58Z","timestamp":1762004278666},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,8,30]],"date-time":"2010-08-30T00:00:00Z","timestamp":1283126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction\u2002<\/jats:bold> Acrodermatitis enteropathica is a rare autosomal recessive disease due to an abnormality in a zinc transporting molecule.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We conducted a retrospective monocentric study on 29 Tunisian cases of Acrodermatitis enteropathica (AE) treated in our Department of Dermatology in Tunisia, between January 1981 and June 2008.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The age of onset of disorders was between 15 d and 12 months (mean 6.86\u2003\u00b1\u20033.25 months). The delay of consultation ranged between 15 d and 8 months (mean of 2.8\u2003\u00b1\u20032.17 months) after onset. Onset of gastrointestinal and psychiatric signs depended significantly on consulting times. Plasma zinc levels ranged between 14 and 88 lg\/100\u2003ml (mean 44.86\u2003\u00b1\u200318.4 lg\/100\u2003ml). There was not a significant relation between zincemia and clinical features. Genetic analyses in 13 of our patients showed three different mutations in the SLC39A4 gene: c.1223_1227del (p.Trp411ArgfsX7) in exon 7,c.143T&gt;G (p.Leu48X) in exon 1 and c.1784T&gt;C (p.Gly595Val) in exon 11. No significant genotype\u2010phenotype correlations could be established.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Acrodermatitis enteropathica is a rare disease which diagnosis is easy. Its biological confirmation is made on a simple dosage of zincemia. However, the diagnosis is not always suggested, and is unfortunately made late. At present, there is a molecular test to detect SLC39A4 mutations.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04566.x","type":"journal-article","created":{"date-parts":[[2010,9,11]],"date-time":"2010-09-11T00:14:59Z","timestamp":1284164099000},"page":"1038-1044","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tropical medicine rounds: Acrodermatitis enteropathica: a review of 29 Tunisian cases"],"prefix":"10.1111","volume":"49","author":[{"given":"Monia","family":"Kharfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"El 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