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Drug intake is a major concern in this respect, as new drugs are constantly being added to the list of factors that may influence the course of this disease. Drug ingestion may result in exacerbation of pre\u2010existing psoriasis, in induction of psoriatic lesions on clinically uninvolved skin in patients with psoriasis, or in precipitation of the disease in persons without family history of psoriasis or in predisposed individuals. In view of their relationship to drug\u2010provoked psoriasis, therapeutic agents may be classified as drugs with strong evidence for a causal relationship to psoriasis, drugs about which there are considerable but insufficient data to support the induction or aggravation of the disease, and drugs that are occasionally reported to be associated with aggravation or induction. This review focuses on the most common causative agents for drug\u2010induced, drug\u2010triggered, or drug\u2010aggravated psoriasis, such as \u03b2\u2010blockers, lithium, synthetic antimalarial drugs, nonsteroidal anti\u2010inflammatory agents, and tetracyclines, and the mechanisms of action of these drugs in the pathogenesis of psoriasis.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04570.x","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T07:50:12Z","timestamp":1290498612000},"page":"1351-1361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["The role of drugs in the induction and\/or exacerbation of psoriasis"],"prefix":"10.1111","volume":"49","author":[{"given":"Kabbur Hanumanthappa","family":"Basavaraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navya Mysore","family":"Ashok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Rashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaggikuppe Krishnamurthy","family":"Praveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"e_1_2_18_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569520500536568"},{"key":"e_1_2_18_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001030-00003"},{"key":"e_1_2_18_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70265-X"},{"key":"e_1_2_18_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4857-7_32"},{"key":"e_1_2_18_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb02419.x"},{"key":"e_1_2_18_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00214.x"},{"key":"e_1_2_18_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331970205300617"},{"key":"e_1_2_18_9_2","first-page":"95","article-title":"Psoriasiform eruption induced by propranolol","volume":"24","author":"Halevy S","year":"1979","journal-title":"Cutis"},{"key":"e_1_2_18_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1984.tb00762.x"},{"key":"e_1_2_18_11_2","first-page":"857","article-title":"Psoriasiform reaction to atenolol","volume":"122","author":"White WB","year":"1986","journal-title":"Arch Dermatol"},{"key":"e_1_2_18_12_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2340\/0001555556239243","article-title":"Aggarvation of psoriasis and occurrence of psoriasiform cutaneous eruptions induced by practolol (Eraldin)","volume":"56","author":"Sondergaard J","year":"1976","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_18_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1978.tb01479.x"},{"key":"e_1_2_18_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01007.x"},{"key":"e_1_2_18_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91909-1"},{"key":"e_1_2_18_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5943.528-a"},{"key":"e_1_2_18_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91750-X"},{"key":"e_1_2_18_18_2","first-page":"1082","article-title":"Arzneimittelexantheme bei der Behandlung mit Beta\u2010blockern","volume":"32","author":"Berowa N","year":"1984","journal-title":"Dtsch Dermatologe"},{"key":"e_1_2_18_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.1.102"},{"key":"e_1_2_18_20_2","first-page":"179","article-title":"Practolol induced drug eruptions","volume":"66","author":"Assem ESK","year":"1973","journal-title":"Proc R Soc Med"},{"key":"e_1_2_18_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1975.tb00184.x"},{"key":"e_1_2_18_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5958.595"},{"key":"e_1_2_18_23_2","first-page":"232","article-title":"Cutaneous reactions to practolol. 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