{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:35:48Z","timestamp":1783485348158,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T00:00:00Z","timestamp":1285632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alopecia areata is an autoimmune disease resulting in partial or total nonscarring hair loss and the treatment of severe alopecia areata is difficult. The aim of this study was to evaluate the efficacy and safety of azathioprine as a systemic monotherapy for moderate to severe alopecia areata. A total of 20 patients [14 men (70%) and six women (30%)] with minimum 6\u2003months history of alopecia areata were included. The extent of scalp hair regrowth during and after the completion of the 6\u2003months treatment was evaluated by the Severity of Alopecia Tool (the SALT score). The daily drug intake was calculated as 2\u2003mg\/kg of body weight. Mean duration of current episode of scalp hair loss was 26.4 (26.4\u2003\u00b1\u200317) months. Mean regrowth percentage was 52.3% (52.3\u2003\u00b1\u200338.4). Mean hair loss percentage before treatment was 72.7% (72.7\u2003\u00b1\u200328.3) compared with 33.5% (33.5\u2003\u00b1\u200330.7) after 6\u2003months of azathioprine treatment. This showed a highly significant statistical difference (Paired <jats:italic>t<\/jats:italic>\u2010test, CI 95%\u2003=\u200321.5\u201354.1). Mean hair loss score (S<jats:sub>0<\/jats:sub>\u2013S<jats:sub>5<\/jats:sub>) before treatment was 3.9 (3.9\u2003\u00b1\u20031.6) and after 6\u2003months of azathioprine treatment was 1.8 (1.8\u2003\u00b1\u20031.3). Assessment showed significant difference from baseline score (sign test, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). No significant statistical difference was observed with respect to gender before and after azathioprine treatment. Treatment with azathioprine as a systemic monotherapy clinically produces relevant improvement in moderate\u2010to\u2010severe alopecia areata. Generally azathioprine is a low\u2010cost and well\u2010tolerated drug and with controlled studies on larger number of patients, long\u2010term efficacy and safety of this treatment should be investigated.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04576.x","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T16:07:24Z","timestamp":1285690044000},"page":"1188-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Could azathioprine be considered as a therapeutic alternative in the treatment of alopecia areata? A pilot study"],"prefix":"10.1111","volume":"49","author":[{"given":"Susan","family":"Farshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvin","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Safar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samad Rezaee","family":"Khiabanloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03193.x"},{"key":"e_1_2_6_3_2","unstructured":"CamachoFM RandallVA PriceVH.Hair and its disorders. Biology pathology and management. 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