{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:34:29Z","timestamp":1767713669733},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T00:00:00Z","timestamp":1298419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> Nadifloxacin is a fluoroquinolone with broad\u2010spectrum antibacterial activity. Although it is used as an acne treatment in some European countries, it has not been used to treat Korean acne patients. We aimed to evaluate the clinical efficacy and safety of 1% nadifloxacin cream and the histological changes it incurs when used to treat mild to moderate facial acne in Korean patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> An eight\u2010week, randomized, prospective, split\u2010face, double\u2010blind, vehicle\u2010controlled trial was performed. All participants were treated with 1% nadifloxacin cream on one\u2010half of the face and vehicle cream on the other, twice per day for eight\u2003weeks.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> At final visits, inflammatory acne lesions were reduced by 70% on nadifloxacin\u2010treated skin and increased by 13.5% on vehicle\u2010treated skin; non\u2010inflammatory acne lesions showed reductions of 48.1 and 10.1%, respectively. A significant difference was observed between the two treatments at four\u2003weeks. Histopathological examinations of the acne lesions showed decreased inflammation and interleukin\u20108 expression but no change in transforming growth factor\u2010\u03b2 expression in nadifloxacin\u2010treated skin compared with vehicle\u2010treated skin after eight\u2003weeks of treatment.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Nadifloxacin 1% cream is an effective, safe, and well\u2010tolerated topical treatment for Korean patients with mild to moderate acne vulgaris. Histopathological changes after nadifloxacin treatment were well correlated with clinical outcomes. Therefore, nadifloxacin can be used as an effective and safe treatment option in the management of mild to moderate acne in Asian subjects.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04701.x","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T10:25:25Z","timestamp":1298456725000},"page":"350-357","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical and histological evaluation of 1% nadifloxacin cream in the treatment of acne vulgaris in Korean patients"],"prefix":"10.1111","volume":"50","author":[{"given":"Jae Yoon","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuck Hoon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kkot 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