{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:08:19Z","timestamp":1771301299587,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,3,18]],"date-time":"2011-03-18T00:00:00Z","timestamp":1300406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Actinomycetomas are chronic, granulomatous, subcutaneous infections caused by the traumatic inoculation of actinomycetes bacteria into the skin which produces nodular lesions with draining sinuses and discharging grains. Actinomycetomas can cause profound disability, and despite long\u2010term chemotherapy, treatment failure is common.<\/jats:p><jats:p><jats:bold>Aims\u2002<\/jats:bold> We investigated the efficacy of a novel drug regimen for the treatment of a severe case of Nocardia actinomycetoma of the leg.<\/jats:p><jats:p><jats:bold>Material and Methods\u2002<\/jats:bold> A 31\u2010year\u2010old man was treated with an initial three\u2010week parenteral course of meropenem and amikacin combination therapy followed by long term oral sulphonamides.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Treatment was well\u2010tolerated with no adverse effects, and there was complete clinical and microbiological cure with no recurrence.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Meropenem and amikacin combination therapy represents an important addition to the currently available treatments for actinomycetomas.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04748.x","type":"journal-article","created":{"date-parts":[[2011,3,18]],"date-time":"2011-03-18T08:32:20Z","timestamp":1300437140000},"page":"443-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Successful treatment of <i>Nocardia<\/i> actinomycetoma with meropenem and amikacin combination therapy"],"prefix":"10.1111","volume":"50","author":[{"given":"Mahreen","family":"Ameen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa V\u00e1squez del","family":"Mercado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,18]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"477","article-title":"Epidemiology of mycetoma in Mexico: study of 2105 cases","volume":"128","author":"L\u00f3pez\u2010Mart\u00ednez R","year":"1992","journal-title":"Gac Med Mex"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.883"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)00009-9"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.832-837.2004"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp144"},{"key":"e_1_2_4_7_2","first-page":"130","article-title":"Clinical experiences of pulmonary and bloodstream nocardiosis in two tertiary care hospitals in northern Taiwan, 2000\u20132004","volume":"41","author":"Tuo MH","year":"2008","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.043"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.05.011"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.12.2077"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01102-06"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101560050022"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(02)00269-8"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2010.04748.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2010.04748.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T09:43:44Z","timestamp":1697363024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2010.04748.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,18]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1111\/j.1365-4632.2010.04748.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2010.04748.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,18]]},"assertion":[{"value":"2011-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}