{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:11:47Z","timestamp":1791101507255,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T00:00:00Z","timestamp":1311292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Skin exposure to ultraviolet (UV) B radiation leads to epidermal damage and generation of reactive oxygen species. The photoprotective effect of extracts of three varieties of leaves (red, yellow, and black) from maca (<jats:italic>Lepidium meyenii<\/jats:italic>), a plant from the Peruvian highlands, was assessed in mouse skin exposed to UVB radiation.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold>The hydroalcoholic extracts of three varieties of maca leaves were applied topically to the dorsal skin of young\u2013adult male mice prior to exposition to UVB radiation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>The three varieties had UVA\/UVB absorptive properties and presented antioxidant activity, being highest with red maca, followed by black and yellow maca. The three varieties of maca leaves prevented the development of sunburn cells, epidermal hyperplasia, leukocytic infiltration, and other alterations produced by UVB radiation. Mice treated with black maca showed the highest superoxide dismutase levels, and mice treated with black and yellow maca showed higher catalase levels in skin, whereas red maca protected the skin and liver against significant increases in the lipid peroxidation activity observed in the unprotected animals.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold>The presence of significant antioxidant activity and the inhibition of lipid peroxidation suggest that the observed protection could be partly attributable to this mechanism.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04793.x","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T13:48:49Z","timestamp":1311515329000},"page":"928-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Photoprotection against the UVB\u2010induced oxidative stress and epidermal damage in mice using leaves of three different varieties of<i>Lepidium meyenii<\/i>(maca)"],"prefix":"10.1111","volume":"50","author":[{"given":"Cynthia","family":"Gonzales\u2010Casta\u00f1eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luc\u00eda","family":"Chirinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Evelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Francisco","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04S1007.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35002510"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2006.003"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00408.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2004.00111.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00902.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00693.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00206-7"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372003"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.035"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.14"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2008.00330.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jdermsci.2009.06.004","article-title":"Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein\u201070 expression in mouse skin by topical application of algal UV\u2010absorbing compounds","volume":"55","author":"de la Coba F","year":"2009","journal-title":"J Dermatol Sci"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00818.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0193"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2006.12.002"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.2165\/00139709-200524010-00002"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-3-5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2007.00783.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nen063"},{"key":"e_1_2_7_22_2","volume-title":"Guide on the Care and Use of Laboratory Animals","author":"National Research Council","year":"1996"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf990146l"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01749.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2051"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02045.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf00018a005"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erm316"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00074.x"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08708.x"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00238.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-009-0324-z"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1992.tb03510.x"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00245-7"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406070200"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1039\/B504970A"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00394.x"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00619.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.137"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-6-23"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.035"},{"key":"e_1_2_7_43_2","volume-title":"Protection of the Skin Against Ultraviolet Radiations","author":"Cohen C","year":"1998"},{"key":"e_1_2_7_44_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.33549\/physiolres.930174","article-title":"Protective effects of topical alpha\u2010tocopherol acetate on UVB irradiation in guinea pigs: importance of free radicals","volume":"51","author":"Saral Y","year":"2002","journal-title":"Physiol Res"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.05.015"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(02)00024-7"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90550-9"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(96)07437-4"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00268-7"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf8005307"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920008786049267"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80421"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-006-1093-z"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2010.04793.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2010.04793.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:14:48Z","timestamp":1712621688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2010.04793.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,22]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1111\/j.1365-4632.2010.04793.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2010.04793.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,22]]},"assertion":[{"value":"2011-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}