{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:20:41Z","timestamp":1761895241152},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T00:00:00Z","timestamp":1299456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Cutaneous T\u2010cell lymphoma is a rare condition that represents 2% of all lymphomas and 75\u201380% of primary cutaneous lymphomas. The objective of the present study is to evaluate a clinical practice guideline.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> This paper reports a prospective cohort study with a five\u2010year follow\u2010up. This is the second report to describe the analysis of data obtained during follow\u2010up of 28\u2003months. To date, 40 patients diagnosed with early\u2010stage mycosis fungoides (stage IA, <jats:italic>n<\/jats:italic>\u2003=\u200320; stage IB, <jats:italic>n<\/jats:italic>\u2003=\u200320) have been enrolled. All patients have been treated with a minimum of 58 sessions of psoralen and long\u2010wave ultraviolet radiation, with complete clinical and histological clearance of lesions. Variables considered include disease duration, treatment time, treatment dose, and history of relapse. Complete physical examinations and diverse complementary examinations were performed. A tumor\u2013node\u2013metastasis\u2013blood staging system was applied. The population was divided into two groups according to results consisting, respectively, of those who relapsed during follow\u2010up (<jats:italic>n\u2003<\/jats:italic>=\u200312) and those who did not (<jats:italic>n<\/jats:italic>\u2003=\u200328).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> History of relapse was the variable most strongly associated with future relapse (relative risk\u2003=\u200310.38, 95% confidence interval 2.64\u201340.72). No statistically significant difference between the groups according to receipt of maintenance therapy was found (<jats:italic>P<\/jats:italic>\u2003=\u20030.161).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our results strongly suggest that maintenance therapy does not prevent future relapse. However, history of relapse is a strong predictor for future relapse.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2010.04833.x","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T08:19:16Z","timestamp":1299485956000},"page":"1086-1093","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Is PUVA maintenance therapy necessary in patients with early\u2010stage mycosis fungoides? Evaluation of a treatment guideline over a 28\u2010month follow\u2010up"],"prefix":"10.1111","volume":"50","author":[{"given":"Mar\u00eda A.","family":"S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel F.","family":"Gait\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Zuluaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol B.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda T.","family":"de Galvis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.025"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.01846.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.08.043"},{"key":"e_1_2_6_5_2","first-page":"1386","volume-title":"Fitzpatrick\u2019s Dermatology in General Medicine","author":"Assaf C","year":"2008"},{"key":"e_1_2_6_6_2","first-page":"790","article-title":"Immunopathogenesis and therapy of cutaneous T cell lymphoma","volume":"118","author":"Kim EJ","year":"2005","journal-title":"J Clin Invest"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.126.7.914"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.033"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.041"},{"key":"e_1_2_6_10_2","first-page":"2373","volume-title":"Textbook of Dermatology","author":"McKie RM","year":"1998"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.7.1111"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.889"},{"key":"e_1_2_6_13_2","first-page":"67","article-title":"Is PUVA maintenance therapy necessary in patients with early\u2010stage mycosis fungoides? 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