{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:39:26Z","timestamp":1792100366436,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,9,25]],"date-time":"2011-09-25T00:00:00Z","timestamp":1316908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> The use of antiretroviral therapy (ART) in AIDS has been associated with lipodystrophic syndrome, which is characterized by metabolic alterations and abnormal corporal fat distribution. Our goal was to describe and evaluate the use of polymethylmethacrylate (PMMA) to treat lipoatrophy in patients with AIDS from Amazonas, Brazil.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Patients with AIDS undergoing ART and presenting with facial lipoatrophy were invited to participate in the study. A face\u2010to\u2010face interview was conducted, and patients were treated with applications of PMMA 30%.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 49 cases were included. The mean age was 45 (SD 6.1)\u2003years old, and the mean educational level (measured in schooling years) was 10.5 (SD 3.2)\u2003years of schooling. The median of CD4 cell count was 482.5 (interquartile range: 338\u2013574.5)\u2003cells\/mm<jats:sup>3<\/jats:sup>. Stavudine and zidovudine were the most frequently prescribed ART drugs. The total number of PMMA injections ranged from one to five times, and side effects were not frequent. A total of 42 (85.7%) patients reported satisfaction after a follow\u2010up of more than 12\u2003months, presenting good fullness of the deformity.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our data showed that patients with AIDS with lipoatrophy related to ART could safely benefit from PMMA\u2010based treatment.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.04926.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T20:12:33Z","timestamp":1317154353000},"page":"1255-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lipoatrophy in patients with AIDS: treatment with polymethylmethacrylate in Amazonas, Brazil"],"prefix":"10.1111","volume":"50","author":[{"given":"Ana Tereza","family":"Orsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Espinosa","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Cavalcante","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila Cristina","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Reis","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Talhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinesio","family":"Talhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000182230.47819.aa"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702008000400018"},{"key":"e_1_2_5_4_2","first-page":"26","article-title":"The long\u2010term consequences of antiretroviral therapy: a review","volume":"11","author":"Boyd M","year":"2006","journal-title":"J HIV Ther"},{"key":"e_1_2_5_5_2","first-page":"93","article-title":"HIV\u2010associated facial lipoatrophy \u2013 review of current therapy options","volume":"13","author":"Bechara FG","year":"2008","journal-title":"Eur J Med Res"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776055796"},{"key":"e_1_2_5_7_2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1177\/135965350400900609","article-title":"Complications associated with NRTI therapy: update on clinical features and possible pathogenic mechanisms","volume":"9","author":"Nolan D","year":"2004","journal-title":"Antivir Ther"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03363.x"},{"key":"e_1_2_5_9_2","unstructured":"Minist\u00e9rio da Sa\u00fade.Manual de Tratamento Lipoatrofia facial em pacientes portadores de HIV\/AIDS com polimetilmetacrilato (PMMA). Bras\u00edlia:Programa Nacional de DST\/AIDS;2005:17\u201326."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32303.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30406.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000183629.20041.bb"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31802bf122"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2005.00334.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000214811.72916.67"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.2310\/6350.2005.31242"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01216.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2011.04926.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2011.04926.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T10:50:31Z","timestamp":1697367031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2011.04926.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,25]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1365-4632.2011.04926.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2011.04926.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,25]]},"assertion":[{"value":"2011-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}