{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:47:21Z","timestamp":1790981241226,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T00:00:00Z","timestamp":1306713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Isotretinoin is widely used in the treatment of extensive and nodulocystic acne. The objective of this prospective study was to investigate whether oral isotretinoin could affect the hearing system. Thirty\u2010eight patients with acne vulgaris (76 ears) who were diagnosed and treated at the Department of Dermatology were included in the current study. Study evaluation visits were performed at baseline and at Weeks 1, 2 and 3. Pure\u2010tone averages (PTAs) of air conduction thresholds at 250\u2003Hz (PTA1); 500, 1000, and 2000\u2003Hz (PTA2); 4000, 8000, and 10,\u2003000\u2003Hz (PTA3); and 12,\u2003500, 16,\u2003000, 18,\u2003000 and 20,\u2003000\u2003Hz (PTA4) for each ear were calculated separately. Assessment of the efficacy was based on the audiometric findings. Compared with pre\u2010treatment evaluation, the PTAs of patients were found to be significantly different at the first week for PTA2 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.033) and PTA3 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.001), at the second week for PTA1 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.036), and at the third week for PTA4 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.002). Our results suggest that the oral isotretinoin (13\u2010\n                    <jats:italic>cis<\/jats:italic>\n                    retinoic acid), which is a derivative of retinol (vitamin A), improved the hearing level of the patients in all audiometric frequencies in a short\u2010period follow\u2010up.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.04959.x","type":"journal-article","created":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T05:37:51Z","timestamp":1306733871000},"page":"1139-1143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of oral isotretinoin (13\u2010\n                    <i>cis<\/i>\n                    retinoic acid) on hearing systems in patients with acne vulgaris: a prospective 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