{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:19:34Z","timestamp":1791386374980,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T00:00:00Z","timestamp":1340150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Lichen planus (LP) is an inflammatory disease of the skin and oral mucosa. The association of LP and chronic hepatitis C virus (HCV) is well established, with variable prevalence rates among different populations. Toll\u2010like receptors (TLRs) are key regulators of both the innate response and the adaptive response. However, TLRs also interact with endogenous ligands released by necrotic cells, and this process can intensify autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To investigate the role of Toll\u2010like receptor\u20107 (TLR\u20107) in LP through the detection of TLR\u20107 protein, and to compare between the expression of TLR\u20107 protein in HCV\u2010positive and HCV\u2010negative patients with LP.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> The study included 20 skin biopsies from patients with LP and 10 control biopsies. TLR\u20107 protein was detected by Western blot analysis. Detection of HCV\u2010specific antibodies in the patient serum was done using ELISA technique.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Our analysis revealed a significantly lower level of TLR\u20107 protein in all the LP skin biopsies compared with controls. The expression showed no difference between HCV\u2010positive and HCV\u2010negative patients.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> We concluded that TLR\u20107 abnormal expression in LP may have an impact on the pathogenesis of the disease. TLR\u20107 receptor and HCV relationship in patients with LP could not be confirmed by this study.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.04977.x","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T13:29:06Z","timestamp":1340285346000},"page":"785-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Downregulation of TLR\u20107 receptor in hepatic and non\u2010hepatic patients with lichen planus"],"prefix":"10.1111","volume":"51","author":[{"given":"Amira","family":"El 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