{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:48:09Z","timestamp":1772160489766,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T00:00:00Z","timestamp":1318896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Progressive macular hypomelanosis (PMH) is a dermatosis of unknown etiology. It has been concluded that it involves the presence of\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    , a saprophyte of the pilosebaceous follicles. In our study, we investigated the presence of\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    in lesional and non\u2010lesional skin of patients with PMH through quantitative real\u2010time polymerase chain reaction (PCR) and bacterial culture from a skin fragment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods\u2002<\/jats:bold>\n                    An observational, exploratory study, with laboratory comparison of lesional (study group) and non\u2010lesional skin (comparison group), in patients with PMH, was carried out with 36 patients, seen in the dermatology outpatient setting at the Oswaldo Cruz University Hospital (OCUH), Recife, Pernambuco, Brazil, between March and May 2008. All patients were submitted to a Wood\u2019s lamp examination, mycological research, and biopsies of lesional and non\u2010lesional skin from the back. Skin fragments were submitted to a histopathology test, bacterial culture, and a quantitative real\u2010time PCR test. The program Statistical Package for Social Sciences, version 12.0, was employed for relationship analysis with the Wilcoxon and McNemar tests.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    There was a significant predominance of\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    on lesional skin, in comparison to non\u2010lesional skin (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    &lt;\u20030.001), as demonstrated by culture and quantitative real\u2010time PCR.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    Although\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    is a saprophyte, the hypothesis may be raised that this microorganism participates in the development of PMH.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.04978.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T02:52:12Z","timestamp":1318906332000},"page":"1347-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Investigation of\n                    <i>Propionibacterium acnes<\/i>\n                    in progressive macular hypomelanosis using real\u2010time PCR and culture"],"prefix":"10.1111","volume":"50","author":[{"given":"Silvana Maria","family":"de Morais Cavalcanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel Rodrigues","family":"de Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Kelly","family":"Lins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane Ruth Barbosa","family":"de Alencar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02755.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.2.210"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708010-00002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.03.020"},{"key":"e_1_2_6_6_2","first-page":"622","volume-title":"I. 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