{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:15:42Z","timestamp":1773173742905,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Derangements in blood cell counts have been described in patients with Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) but are not well characterized. We aim to describe the relationship between our patients\u2019 hematological results and the evolution of disease and hypothesize on the possible roles of granulocyte\u2010colony\u2010stimulating factor (G\u2010CSF) in the management of these conditions.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> Clinical records of our patients with SJS and TEN from January 2005 to 2010 were analyzed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Anemia and lymphopenia were most commonly seen, while thrombocytopenia was uncommon. Leukopenia and neutropenia were seen in patients with more severe disease, and the trend of leukopenia and neutropenia followed the evolution of disease. Two patients received G\u2010CSF for febrile neutropenia and had a rapid recovery of their neutrophil counts as well as a shorter time to re\u2010epithelialization.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our patients tended to have leukopenia and neutropenia that followed a predictable trend of decline and subsequent improvement depending on the stage of disease. This may be of pathogenic significance, and G\u2010CSF may be used in these cases to manage febrile neutropenia and aid re\u2010epithelialization. Further basic science research is required to prove our hypotheses.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.05007.x","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T06:59:09Z","timestamp":1321858749000},"page":"1570-1578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hematological abnormalities and the use of granulocyte\u2010colony\u2010stimulating factor in patients with Stevens\u2013Johnson syndrome and toxic epidermal necrolysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Chia\u2010Chun","family":"Ang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Kwang","family":"Tay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09585.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2009.00540.x"},{"key":"e_1_2_7_4_2","first-page":"392","article-title":"Toxic epidermal necrolysis treated with intravenous immunoglobulin and granulocyte colony\u2010stimulating factor","volume":"41","author":"Kalyoncu M","year":"2004","journal-title":"Indian Pediatr"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200309000-00012"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199909000-00015"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1997.tb01044.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb01167.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02806.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03826.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(90)90165-S"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660330071012"},{"key":"e_1_2_7_13_2","first-page":"807","article-title":"Lyell\u2019s syndrome and ectodermosis pluriorificialis during treatment with oxicams: 11 cases","volume":"112","author":"Guillaume JC","year":"1985","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_7_14_2","first-page":"113","article-title":"Hematologic anomalies in Lyell\u2019s syndrome. 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